1. 成分信息
| 英文名: | Celastrol |
| 中文名: | 雷公藤红素 |
| CAS编号: | 34157-83-0 |
| 分子式: | C29H38O4 |
| 分子量: | 450.6 |
| SMILES: | CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O |
2. 相关药材
| 中文名称 | 英文名称 | 拉丁文名称 |
| 粗毛南蛇藤 | Hirsute Bittersweet | Celastrus strigillosus |
| 东北雷公藤 | Radix Tripterygii regeli | - |
| 黑曼巴 | Regel Threewingnut | Tripterygium regelii |
| 火麻仁 | Hemp Seed | Semen Canbis;Fructus Canbis |
| 昆明山海棠 | Glaucousback Threewingnut | Tripterygium hypoglaucum |
| 雷公藤 | root of common htreewingnut | radix tripterygii wilfordii |
| 美洲南蛇藤 | American Bittersweet | Celastrus scandens |
| 南蛇藤根 | Oriental Bittersweet Root | Celastrus orbiculatus [Syn. Celastrus articulatus |
| 南蛇藤果 | Celastri Orbiculati Fructus | - |
3. 相关靶点
| 基因靶点 | 靶点位置 | 参考文献 |
| ABCB1 | 7q21.12 | 31982489 |
| Abcb1a | 5 A1|5 3.43 cM | 31982489 |
| AKT1 | 14q32.33 | 31053160 |
| ALOX5 | 10q11.21 | 27597642 |
| ANXA5 | 4q27 | 22641218 |
| BAG3 | 10q26.11 | 24351928 |
| BAX | 19q13.33 | 23846217 |
| BCL2 | 18q21.33 | 21506956 |
| BCL2L1 | 20q11.21 | 21506956 |
| BSG | 19p13.3 | 29987023 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Acute kidney injury | disease | 30268831 |
| Alzheimer's Disease | disease | 24849358 |
| Arthritis | disease | 31124139 |
| Arthritis | disease | 21501142 |
| Arthritis, Experimental | disease | 22415021 |
| Brain Infarction | disease | 29540209 |
| Brain Ischemia | disease | 29540209 |
| Brain Neoplasms | group | 24810052 |
| Cardiomegaly | phenotype | 29987023 |
| Edema | phenotype | 27597642 |
