1. 药材主信息
| 中文名称: | 雷公藤 |
| 英文名称: | root of common htreewingnut |
| 拉丁名称: | radix tripterygii wilfordii |
| 使用部位: | root, leaf and flower |
| 功用: | To expel wind-dampness, relieve swelling, alleviate pain and dredge the meridian passage. |
| 适用症: | Rheumatoid arthritis, rheumatic arthritis, glomerulonephritis, nephropathy syndrome, erythematous lupus, dryness in eyes and mouth, Behcet’s syndrome, psoriasis, eczema, leprosy, scab sore, intractable lichen. |
| 毒副作用: | Slightly Toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 99-83-2 | 水芹烯 | - | 7460 |
| 7785-70-8 | (1R)-(+)-alpha-蒎烯 | (+)-alpha-Pinene | 82227 |
| 7785-53-7 | - | (+)-alpha-Terpineol | 442501 |
| 14464-90-5 | Lyoniresinol | (+)-Lyoniresinol | 11711453 |
| 5655-61-8 | - | (2S,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl acetate | 44630108 |
| 66851-47-6 | - | 1,2-Benzenedi(carboxylic-14C)acid, dibutyl ester | 171810 |
| 128341-04-8 | - | 1,8-Dihydroxy-4-hydroxymethylanthraquinone | 124869 |
| 564-16-9 | - | 11-Deoxoglycyrrhetinic acid | 12305517 |
| 3117-03-1 | 2,5-二甲氧基-1,4-苯醌 | 2,5-Dimethoxy-1,4-benzoquinone | 101405 |
| 642-71-7 | 3,4,5-三甲氧基苯酚 | 3,4,5-Trimethoxyphenol | 69505 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCB1 | ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1 | 7q21.12 | 31982489 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 24107776 |
| Abcb1a | Abcb4; Evi32; Mdr1a; Mdr3; P-gp; Pgp; Pgy-3; Pgy3; mdr-3 | 5 A1|5 3.43 cM | 31982489 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 24107776 |
| ABCG2 | ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1 | 4q22.1 | 26597727 |
| ABCG5 | STSL; STSL2 | 2p21 | 24107776 |
| ABCG8 | GBD4; STSL; STSL1 | 2p21 | 24107776 |
| AGT | ANHU; SERPINA8; hFLT1 | 1q42.2 | 21844078 |
| AGT | ANHU; SERPINA8; hFLT1 | 1q42.2 | 21223972 |
| AGT | ANHU; SERPINA8; hFLT1 | 1q42.2 | 20942814 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Acute kidney injury | disease | 21719790 |
| Acute kidney injury | disease | 30268831 |
| Alzheimer's Disease | disease | 24849358 |
| Arthritis | disease | 31124139 |
| Arthritis | disease | 21501142 |
| Arthritis, Experimental | disease | 22415021 |
| Autoimmune Diseases | group | 26996065 |
| Blood Pressure | phenotype | 21321301 |
| Body Weight | phenotype | 22220673 |
| Bone neoplasms | group | 28965856 |
