1. 药材主信息
| 中文名称: | 昆明山海棠 |
| 英文名称: | Glaucousback Threewingnut |
| 拉丁名称: | Tripterygium hypoglaucum |
| 使用部位: | root |
| 功用: | To dispel wind and eliminate damp, quicken blood and stanch bleeding, soothe sinews and joint bones, resolve toxin and kill worms. |
| 适用症: | Rheumatic arthritis, wind-damp impediment pain, hemiplegia, mounting qi , dysmenorrhea, profuse menstruation, postpartum abdominal pain, incessant bleeding, acute infectious hepatitis, chronic nephritis, erythematous lupus, fracture, medullitis, bone tuberculosis, epididymis tubercle, sore toxin, psoriasis, neurodermatitis. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 79907-44-1 | 原花青素B2-3,3'-二-O-没食子酸酯 | 3,3'-Digalloylprocyanidin B2 | 124016 |
| 34157-83-0 | 雷公藤红素 | Celastrol | 122724 |
| 154-23-4 | (+)-儿茶素 | Cianidanol | 9064 |
| 970-74-1 | 表没食子儿茶素 | Epigallocatechin | 72277 |
| 259823-31-9 | - | Hyponine D | 44593669 |
| 29106-51-2 | 原花青素B4 | Procyanidin B4 | 147299 |
| 29106-51-2 | 原花青素B4 | Procyanidin B4 | 147299 |
| 38647-10-8 | 雷公藤乙素 | Tripdiolide | 294491 |
| 139122-81-9 | 雷公藤福定 | Tripterifordin | 72369 |
| 38748-32-2 | 雷公藤甲素 | Triptolide | 107985 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCG2 | ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1 | 4q22.1 | 26597727 |
| AKR1B1 | ADR; ALDR1; ALR2; AR | 7q33 | 28638477 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 29246323 |
| B4galnt2 | AI593864; Dlb-1; Dlb1; Galg2; Galgt2; Ggm3; Igf2bp1 | 11 D|11 59.02 cM | 30503558 |
| BCL2L11 | BAM; BIM; BOD | 2q13 | 29523159 |
| BIRC5 | API4; EPR-1 | 17q25.3 | 23499892 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 23758884 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 24309928 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 25229559 |
| CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | 2q33.1 | 24662747 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Body Weight | phenotype | 22220673 |
| Bone neoplasms | group | 29096654 |
| Cancer Pain | phenotype | 29096654 |
| Carcinoma, Pancreatic Ductal | disease | 27384421 |
| Carcinoma, Pancreatic Ductal | disease | 26597727 |
| Chronic pain | phenotype | 28300618 |
| Colonic Neoplasms | group | 23758884 |
| Colorectal Neoplasms | group | 31122284 |
| Diabetes Mellitus, Experimental | disease | 30741721 |
| Diabetes Mellitus, Experimental | disease | 23530831 |
