1. 药材主信息
| 中文名称: | 炙厚朴 |
| 英文名称: | Prepared bark of Officinal magnolia |
| 拉丁名称: | Magnoliae Officinalis Praeparata |
| 使用部位: | Magnolia officinalis Rehd. et Wils.;Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils. |
| 功用: | Treatment of accumulation of damp in the spleen and the stomach marked by epigastric strffiness, vomiting and diarrhea, abdominal distension and constipation due to retention of undigested food, cough and dyspnea caused by retanied damp. |
| 适用症: | 1. Broad-spectrum antibacterial.2. Magnocurarine, one of the active components, can relaxstriated muscles.3. Its decoction stimulates the smooth muscles of intestines and bronchii in rabbits in vitro.4. Magnocuraine may also lower blood pressure and accelerate heart rate. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 481-74-3 | 大黄酚 | Chrysophanic acid | 10208 |
| 518-82-1 | 大黄素 | Emodin | 3220 |
| 35354-74-6 | 和厚朴酚 | Honokiol | 72303 |
| 6801-40-7 | 木兰箭毒碱 | Magnocurarine | 53266 |
| 528-43-8 | 厚朴酚 | Magnolol | 72300 |
| 478-43-3 | 大黄酸 | Rhein | 10168 |
| 81-27-6 | 番泻苷A | Senna | 73111 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ADAMTS4 | ADAMTS-2; ADAMTS-4; ADMP-1 | 1q23.3 | 29649568 |
| ADAMTS5 | ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADMP-2 | 21q21.3 | 29649568 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24157255 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 26454217 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27940017 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 30587839 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21757288 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31905887 |
| ALPL | AP-TNAP; APTNAP; HOPS; TNALP; TNAP; TNSALP | 1p36.12 | 25832436 |
| ALPP | ALP; ALPI; IAP; PALP; PLAP; PLAP-1 | 2q37.1 | 25832436 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Acute Lung Injury | disease | 21279327 |
| Brain Edema | phenotype | 30597199 |
| Brain Ischemia | disease | 30597199 |
| Brain Neoplasms | group | 22259050 |
| Cardiomegaly | phenotype | 25871545 |
| Cerebral Hemorrhage | phenotype | 30597199 |
| Endotoxemia | phenotype | 21279327 |
| Fibrosis | phenotype | 21265825 |
| Glioblastoma | disease | 30587839 |
| Glioma | disease | 30587839 |
