1. 药材主信息
| 中文名称: | 乌头 |
| 英文名称: | Common Monkshood Equivalent plant: Aconitum karako |
| 拉丁名称: | Aconitum carmichaeli |
| 使用部位: | tuberoid |
| 功用: | To dispel wind and eliminate damp, warm channels, dissipate cold and relieve pain. |
| 适用症: | Wind-cold-damp impediment, pain in joints, numbness in limbs, hemiplegia, head wind headache, cold pain in heart and abdomen, cold mounting with pain, stasis pain from knocks and falls, swelling toxin of flat abscess. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 109985-90-2 | - | Carnosifloside I | 11953915 |
| 5843-65-2 | 去甲乌药碱 | Higenamine | 114840 |
| 41546-34-3 | D-手性肌醇 | Inositol | 892 |
| 549-07-5 | - | Insularine | 10348927 |
| 39089-30-0 | 多根乌头碱 | Karacoline | 441742 |
| 521-88-0 | 水黄皮素 | Karanjin | 100633 |
| 54-04-6 | - | Mescaline | 4076 |
| 96574-01-5 | 丹酚酸A | Salvianolic acid A | 5281793 |
| 145572-44-7 | 槐果碱 | Sophocarpine | 115269 |
| 66-22-8 | 尿嘧啶 | Uracil | 1174 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24486344 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31193821 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 26945965 |
| ALOX5 | 5-LO; 5-LOX; 5LPG; LOG5 | 10q11.21 | 24033467 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 27609227 |
| BCL2L11 | BAM; BIM; BOD | 2q13 | 31193821 |
| BDNF | ANON2; BULN2 | 11p14.1 | 27609227 |
| CDK5 | LIS7; PSSALRE | 7q36.1 | 27609227 |
| CDK5R1 | CDK5P35; CDK5R; NCK5A; p23; p25; p35; p35nck5a | 17q11.2 | 27609227 |
| CREB1 | CREB; CREB-1 | 2q33.3 | 31924228 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Brain Ischemia | disease | 27609227 |
| Cerebral Ischemia | disease | 31193821 |
| Head and Neck Neoplasms | group | 28571917 |
| Inflammation | phenotype | 24033467 |
| Liver neoplasms | group | 26945965 |
| Macular degeneration | disease | 24486344 |
| Myocardial Ischemia | disease | 30361065 |
| Pneumonia | disease | 31969071 |
| Reperfusion Injury | disease | 31193821 |
| Reperfusion Injury | disease | 27609227 |
