1. 药材主信息
| 中文名称: | 苦楝皮 |
| 英文名称: | Meliae Cortex |
| 拉丁名称: | - |
| 使用部位: | - |
| 功用: | - |
| 适用症: | Ascariasis, oxyuria disease, abdominal pain due to worm accumulation, scab and lichen with itching. |
| 毒副作用: | Toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 480-41-1 | - | (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one | 667495 |
| 557-61-9 | 1-二十八烷醇 | 1-Octacosanol | 68406 |
| 1449-09-8 | 24-Methylenecycloartan-3-ol | 24-Methylenecycloartanol | 94204 |
| 67-47-0 | 5-羟甲基糠醛 | 5-Hydroxymethylfurfural | 237332 |
| 65-85-0 | 苯甲酸 | Benzoic Acid | 243 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 108-59-8 | 丙二酸二甲酯 | Dimethyl malonate | 7943 |
| 1135-24-6 | 阿魏酸 | Ferulic acid | 445858 |
| 28808-62-0 | 梣酮 | Fraxinellone | 124039 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 24107776 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 24107776 |
| ABCG5 | STSL; STSL2 | 2p21 | 24107776 |
| ABCG8 | GBD4; STSL; STSL1 | 2p21 | 24107776 |
| AKR1B1 | ADR; ALDR1; ALR2; AR | 7q33 | 21712449 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27710830 |
| APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | 21q21.3 | 24107941 |
| BACE1 | ASP2; BACE; HSPC104 | 11q23.3 | 24107941 |
| CASP1 | ICE; IL1BC; P45 | 11q22.3 | 27641928 |
| CATSPER1 | CATSPER; SPGF7 | 11q13.1 | 28507119 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Bone neoplasms | group | 28783167 |
| Carcinogenesis | phenotype | 28783167 |
| Chronic liver disease | group | 21354229 |
| Colorectal Neoplasms | group | 27710830 |
| Inflammation | phenotype | 27641928 |
| Liver diseases | group | 24107776 |
| Liver neoplasms | group | 25101566 |
| Lung Neoplasms | group | 21748601 |
| Lung Neoplasms | group | 29988033 |
| Necrosis | phenotype | 27710830 |
