1. 药材主信息
| 中文名称: | 大青叶 |
| 英文名称: | Isatis leaf |
| 拉丁名称: | Folium Isatidis |
| 使用部位: | leaf |
| 功用: | To clear heat and toxic materials, cool blood and eliminate eruption. |
| 适用症: | Acute parotitis, encephalitis, hepatitis, lung abscess, acute gastroenteritis, infection of upper respiratory tract, warm evil in construction, ardent fever with clouded spirit, macular eruption and papules, jaundice, heat dysentery, epidemic parotitis, throat impediment, erysipelas, swollen welling abscess. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 7785-26-4 | (1S)-(-)-α-蒎烯 | (-)-alpha-Pinene | 440968 |
| 20307-14-6 | - | (2R,3R,5S,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-(1H-indol-3-yloxy)oxan-4-one | 101529308 |
| 97-67-6 | L-苹果酸 | (2S)-2-Hydroxybutanedioic acid | 222656 |
| 480-93-3 | 3-羟基吲哚 | 1H-Indol-3-ol | 50591 |
| 7471-58-1 | 3-(氯甲基)-6-(三氟甲基)吡啶 | 2(1H)-Quinazolinone | 344381 |
| 3228-71-5 | 2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | 2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | 191 |
| 491-36-1 | 4-羟基喹唑啉 | 4-Hydroxyquinazoline | 135408753 |
| 3416-18-0 | 2-甲基-6-喹啉甲酸 | 5-Hydroxyoxindole | 76955 |
| 73-24-5 | 腺嘌呤 | Adenine | 190 |
| 41547-82-4 | 腺苷 | Adenosine | 60961 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AHR | RP85; bHLHe76 | 7p21.1 | 22533375 |
| AKR1B1 | ADR; ALDR1; ALR2; AR | 7q33 | 21712449 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 22537056 |
| AKT2 | HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA | 19q13.2 | 22537056 |
| CATSPER1 | CATSPER; SPGF7 | 11q13.1 | 28507119 |
| CEBPB | C/EBP-beta; IL6DBP; NF-IL6; TCF5 | 20q13.13 | 22537056 |
| CEBPB | C/EBP-beta; IL6DBP; NF-IL6; TCF5 | 20q13.13 | 27063964 |
| CRTC1 | MAML2; MECT1; Mam-2; TORC-1; TORC1; WAMTP1 | 19p13.11 | 22537056 |
| CTBP1 | BARS; HADDTS | 4p16.3 | 29988033 |
| CTNNB1 | CTNNB; EVR7; MRD19; NEDSDV; armadillo | 3p22.1 | 30081068 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenoma | group | 21693628 |
| Allergic asthma | disease | 28782757 |
| Brain Edema | phenotype | 26337552 |
| Brain Ischemia | disease | 30014516 |
| Brain Ischemia | disease | 24884571 |
| Carcinogenesis | phenotype | 28027595 |
| Colorectal Neoplasms | group | 21693628 |
| Encephalitis | disease | 26337552 |
| Glioma | disease | 30081068 |
| Inflammation | phenotype | 24858719 |
