1. 成分信息
| 英文名: | Rottlerin |
| 中文名: | Rottlerin |
| CAS编号: | 82-08-6 |
| 分子式: | C30H28O8 |
| 分子量: | 516.5 |
| SMILES: | CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C(=C3C(=C2O)C=CC(O3)(C)C)C(=O)C=CC4=CC=CC=C4)O)O |
2. 相关药材
| 中文名称 | 英文名称 | 拉丁文名称 |
| 波叶大黄 | Rheum undulatum Linn | - |
| 茺蔚子 | Motherwort Fruit | Fructus Leonuri |
| 大黄 | root and rhziome of Sorrel Rhubarb | Radix et Rhizoma Rhei |
| 大黄茎 | Rhizoma seu Plantula Rhei palmati | - |
| 倒扣草 | Achyranthis Asperae Herba | - |
| 地瓜子 | Wayaka Yambean Seed | Pachyrhizus erosus |
| 番泻叶 | Sen leaf | Folium Sene |
| 化橘红 | Pummelo Peel | Exocarpium Citri grandis |
| 灰叶根 | Purple Tephrosia Root | Tephrosia purpurea |
| 鸡血藤根 | Leatherleaf Millettia Root | Millettia reticulata |
3. 相关靶点
| 基因靶点 | 靶点位置 | 参考文献 |
| AKT1 | 14q32.33 | 24125861 |
| AKT1 | 14q32.33 | 24359639 |
| AKT1 | 14q32.33 | 25050737 |
| ATG12 | 5q22.3 | 24359639 |
| ATG5 | 6q21 | 24125861 |
| ATG7 | 3p25.3 | 24125861 |
| BAX | 19q13.33 | 25050737 |
| BCL2 | 18q21.33 | 24359639 |
| BCL2 | 18q21.33 | 25050737 |
| BCL2 | 18q21.33 | 25661734 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 25661734 |
| Asthma | disease | 23995289 |
| Colorectal Neoplasms | group | 28570591 |
| Hyperpigmentation | phenotype | 31176710 |
| Liver Neoplasms, Experimental | phenotype | 28570591 |
| melanoma | disease | 27343979 |
| Pancreatic Neoplasm | disease | 25050737 |
| Prostatic Neoplasms | group | 24125861 |
| Skin Neoplasms | group | 27343979 |
