1. 药材主信息
| 中文名称: | 大黄 |
| 英文名称: | root and rhziome of Sorrel Rhubarb |
| 拉丁名称: | Radix et Rhizoma Rhei |
| 使用部位: | root and rhizome |
| 功用: | To cause catharsis and purge away heat, to reduce heat in blood and counteract toxicity, and to eliminate blood stasis and stimulate menstrual discharge. |
| 适用症: | Repletion heat constipation, accumulation with abdominal pain, damp-heat jaundice, acute icterohepatitis, red eyes, swollen throat, intestinal welling abscess and abdominal pain, bleeding of digestive tract, chronic diarrhea, indigestion, acute appendicitis, acute peritonitis, ileus, cholecystitis, gallstones, swollen welling abscess and clove sores, amenorrhea due to blood stasis, knocks and falls, burns and scalds. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 636-61-3 | D-(+)-苹果酸 | - | 92824 |
| 18829-70-4 | (-)-儿茶素 | (-)-Catechin | 73160 |
| 123134-19-0 | - | (3R,5R)-4-[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy-1-hydroxy-3,5-bis[(3,4,5-trihydroxybenzoyl)oxy]cyclohexane-1-carboxylic acid | 442676 |
| 60410-89-1 | - | 10beta-Hydroxy-6beta-isobutyrylfuranoeremophilane | 442377 |
| 577-16-2 | - | 2'-Methylacetophenone | 11340 |
| 577-16-2 | - | 2'-Methylacetophenone | 11340 |
| 56994-83-3 | 2-O-肉桂酰基-1-O-没食子酰基-β-D-葡萄糖苷 | 2-Cinnamoyl-1-galloylglucose | 5315898 |
| 79907-44-1 | 原花青素B2-3,3'-二-O-没食子酸酯 | 3,3'-Digalloylprocyanidin B2 | 124016 |
| 87087-62-5 | - | 3,5-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxan-2-yl]oxybenzoic acid | 11972354 |
| 5471-51-2 | 覆盆子酮 | 4-(4-Hydroxyphenyl)-2-butanone | 21648 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24157255 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24125861 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24359639 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 25050737 |
| ALPL | AP-TNAP; APTNAP; HOPS; TNALP; TNAP; TNSALP | 1p36.12 | 25832436 |
| ALPP | ALP; ALPI; IAP; PALP; PLAP; PLAP-1 | 2q37.1 | 25832436 |
| ASRGL1 | ALP; ALP1; CRASH | 11q12.3 | 25832436 |
| ATG12 | APG12; APG12L; FBR93; HAPG12 | 5q22.3 | 24359639 |
| ATG5 | APG5; APG5-LIKE; APG5L; ASP; SCAR25; hAPG5 | 6q21 | 24125861 |
| ATG7 | APG7-LIKE; APG7L; GSA7 | 3p25.3 | 24125861 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 25661734 |
| Alzheimer's Disease | disease | 30578827 |
| Alzheimer's Disease | disease | 30447302 |
| Asthma | disease | 23995289 |
| Body Weight | phenotype | 24559844 |
| Chromosome Aberrations | group | 23701745 |
| Colorectal Neoplasms | group | 28570591 |
| Diabetic Nephropathy | disease | 21195168 |
| Head and Neck Neoplasms | group | 24157255 |
| Head and Neck Neoplasms | group | 30339884 |
