1. 药材主信息
| 中文名称: | 洋金花 |
| 英文名称: | Datura Flower |
| 拉丁名称: | Flos Daturae |
| 使用部位: | seed , abdomen, wind-damp impediment pain, knocks and falls, epilepsy, chronic fright wind, anesthesia |
| 功用: | To relieve asthma and cough, to alleviate pain, and to arrest spasm. |
| 适用症: | Cough and asthma without phlegm, cold pain in heart and Datura stramonium . |
| 毒副作用: | toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 69251-96-3 | (+)松脂素-β-D-吡喃葡萄糖苷 | (2S,3R,4S,5S,6R)-2-[4-[(3S,3aR,6S,6aR)-3-(4-hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | 486614 |
| 101-31-5 | - | (S)-((1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate | 6931560 |
| 16202-15-6 | - | (S)-Tropic acid | 785356 |
| 60124-17-6 | - | 12-Deoxywithastramonolide | 44576309 |
| 526-13-6 | - | 1alphaH,5alphaH-Tropane-3alpha,6beta,7beta-triol, 3-(2-methylcrotonate), (E)- | 12312780 |
| 99-93-4 | 4'-羟基苯乙酮 | 4'-Hydroxyacetophenone | 7469 |
| 244-63-3 | 9H-吡啶[3,4-b]吲哚 | 9H-Pyrido[3,4-B]indole | 64961 |
| 51-55-8 | 阿托品 | Atropine | 174174 |
| 100-51-6 | 苯甲醇 | Benzyl Alcohol | 244 |
| 17297-56-2 | 山柰酚-3-O-β-刺槐双糖苷 | Biorobin | 15944778 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| BDNF | ANON2; BULN2 | 11p14.1 | 23458470 |
| CXCL1 | FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1 | 4q13.3 | 25281414 |
| IFNG | IFG; IFI | 12q15 | 25281414 |
| IL1B | IL-1; IL1-BETA; IL1F2; IL1beta | 2q14.1 | 25281414 |
| MPO | - | 17q22 | 25281414 |
| PPARGC1A | LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1 | 4p15.2 | 28049156 |
| S100A8 | 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MIF; MRP8; NIF; P8 | 1q21.3 | 25281414 |
| SIRT1 | SIR2; SIR2L1; SIR2alpha | 10q21.3 | 28049156 |
| STAT4 | SLEB11 | 2q32.2-q32.3 | 25281414 |
| TFAM | MTDPS15; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3 | 10q21.1 | 28049156 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Colitis | disease | 25281414 |
| Diabetes | disease | 28049156 |
| Diabetes Mellitus, Experimental | disease | 26185015 |
| Diabetic Cardiomyopathies | disease | 26185015 |
| Memory, Short-Term | phenotype | 23458470 |
| Obesity | disease | 28049156 |
| Ventricular Remodeling | phenotype | 26185015 |
