1. 药材主信息
| 中文名称: | 鸦胆子 |
| 英文名称: | Java Brucea Fruit |
| 拉丁名称: | Fructus Bruceae |
| 使用部位: | fruit |
| 功用: | To remove toxic heat, to stop malarial attacks, to relieve dysentery, and to cauterize vegetations. |
| 适用症: | Malaria, amebic dysentery, dysentery with pus and blood, tenesmus, corn and common wart. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 99132-99-7 | 去氢鸦胆醇 | - | 54604632 |
| 99132-99-7 | 去氢鸦胆醇 | - | 54604632 |
| 520-36-5 | 芹菜素 | Apigenin | 5280443 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 41451-76-7 | - | Bruceantarin | 3084828 |
| 41451-75-6 | 鸦胆亭 | Bruceantin | 5281304 |
| 53729-52-5 | 鸦胆亭醇 | Bruceantinol | 5281305 |
| 25514-30-1 | - | Brucein C | 54601803 |
| 25514-31-2 | 鸦胆子苦素A | Bruceine A | 160006 |
| 25514-31-2 | 鸦胆子苦素A | Bruceine A | 160006 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21871133 |
| BACH1 | BACH-1; BTBD24 | 21q21.3 | 31408727 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 21871133 |
| BCL2L1 | BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 | 20q11.21 | 21871133 |
| CAT | - | 11p13 | 29179721 |
| CD274 | B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; hPD-L1 | 9p24.1 | 27378243 |
| CDC37 | P50CDC37 | 19p13.2 | 21871133 |
| CDK4 | CMM3; PSK-J3 | 12q14.1 | 21871133 |
| CEBPA | C/EBP-alpha; CEBP | 19q13.11 | 29141998 |
| COLQ | CMS5; EAD | 3p25.1 | 28056971 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 21550230 |
| Blood Pressure | phenotype | 28143892 |
| Carcinoma, Ehrlich Tumor | disease | 23348691 |
| Endometrial Hyperplasia | disease | 28638475 |
| Epstein-Barr Virus Infections | group | 28056971 |
| Fibrosis | phenotype | 28143892 |
| Inflammation | phenotype | 27374313 |
| Liver neoplasms | group | 31666108 |
| Liver neoplasms | group | 25445704 |
| Lung Neoplasms | group | 21550230 |
