科华智慧(深圳)创新药物研发有限公司     西北农林科技大学深圳研究院    联合开发

1. 药材主信息

中文名称: 夏天无
英文名称: Decumbent Corydalis Rhizome
拉丁名称: Rhizoma Corydalis Decumbentis
使用部位: tuber
功用: To promote the flow of qi and blood, to remove obstruction from the collaterals and to relieve pain.
适用症: Pain in deep tissues, neuralgia, swelling pain from fracture, hypertension, hemiplegia, sequel of poliomyelitis, sciatica, rheumatic arthritis, knocks and falls.
毒副作用: -

2. 相关成分

CAS号 中文名称 英文名称 参考文献
524-46-9 - (+)-Adlumine 442155
25342-82-9 - (6As)-11-hydroxy-1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinolinium 161487
483-34-1 四氢非洲防己碱 (S)-Tetrahydrocolumbamine 440229
41917-45-7 - 5-(3,4-Methylenedioxyphenyl)pentanoic acid 5321853
550-49-2 - Adlumidine 120734
24240-04-8 别隐品碱 Allocryptopine 98570
24240-04-8 别隐品碱 Allocryptopine 98570
51-55-8 阿托品 Atropine 174174
83-46-5 β-谷甾醇 Beta-Sitosterol 222284
485-49-4 荷包牡丹碱 Bicuculline 10237

3. 相关靶点

基因靶点 基因别名 靶点位置 参考文献
BCL2 Bcl-2; PPP1R50 18q21.33 22033245
CASP1 ICE; IL1BC; P45 11q22.3 31336157
CDK1 CDC2; CDC28A; P34CDC2 10q21.2 22033245
GRIA2 GLUR2; GLURB; GluA2; GluR-K2; HBGR2; gluR-2; gluR-B 4q32.1 21414928
MCL1 BCL2L3; EAT; MCL1-ES; MCL1L; MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT 1q21.2 22033245
NLRP3 AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1 1q44 31336157

4. 相关疾病

疾病名称 疾病类型 参考文献
Neoplasms, Hormone-Dependent phenotype 22033245
Prostatic Neoplasms group 22033245