科华智慧(深圳)创新药物研发有限公司     西北农林科技大学深圳研究院    联合开发

1. 药材主信息

中文名称: 天名精
英文名称: Common Carpesium
拉丁名称: Carpesium abrotanoides
使用部位: root, stem-leaf
功用: To clear heat, transform phlegm, resolve toxin, kill worms, break stasis, stanch bleeding.
适用症: Nipple moth, throat impediment, acute fright wind, chronic fright wind, toothache, swelling toxin of clove sore, hemorrhoids and fistulas, Itchy papules, poisonous snake bite, worm accumulation, blood conglomeration, blood ejection, spontaneous external bleeding, blood strangury, bleeding due to external injury.
毒副作用: -

2. 相关成分

CAS号 中文名称 英文名称 参考文献
483-76-1 (+)-DELTA-CADINENE - 441005
523-47-7 - beta-Cadinene 10657
630-87-5 - Caracurine V 168927
40737-97-1 大叶土木香内酯 Granilin 442254
118-65-0 (-)-异丁香烯 Isocaryophyllene 5281522
83-48-7 豆甾醇 Stigmasterol 5280794
7437-55-0 8-香叶草氧基补骨脂素 Xanthotoxol geranyl ether 5317564
99-86-5 α-松油烯 α-Terpinene 7462

3. 相关靶点

基因靶点 基因别名 靶点位置 参考文献
ABCB11 ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP 2q31.1 24107776
ABCC2 ABC30; CMOAT; DJS; MRP2; cMRP 10q24.2 24107776
ABCG5 STSL; STSL2 2p21 24107776
ABCG8 GBD4; STSL; STSL1 2p21 24107776
APP AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 21q21.3 24107941
BACE1 ASP2; BACE; HSPC104 11q23.3 24107941
NR1H2 LXR-b; LXRB; NER; NER-I; RIP15; UNR 19q13.33 24107776
NR1H3 LXR-a; LXRA; RLD-1 11p11.2 24107776
NR1H4 BAR; FXR; HRR-1; HRR1; PFIC5; RIP14 12q23.1 24107776
TLR4 ARMD10; CD284; TLR-4; TOLL 9q33.1 24107776

4. 相关疾病

疾病名称 疾病类型 参考文献
Liver diseases group 24107776