1. 药材主信息
| 中文名称: | 唐古特大黄 |
| 英文名称: | Tangut Rhubarb |
| 拉丁名称: | Rheum tanguticum |
| 使用部位: | root and rhizome |
| 功用: | See Rheum officinale. |
| 适用症: | See Rheum officinale. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 123134-19-0 | - | (3R,5R)-4-[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy-1-hydroxy-3,5-bis[(3,4,5-trihydroxybenzoyl)oxy]cyclohexane-1-carboxylic acid | 442676 |
| 6869-50-7 | - | 14beta,17alpha-Pregn-5-en-20-one, 3beta,8,12beta,14-tetrahydroxy- | 12311278 |
| 56994-83-3 | 2-O-肉桂酰基-1-O-没食子酰基-β-D-葡萄糖苷 | 2-Cinnamoyl-1-galloylglucose | 5315898 |
| 79907-44-1 | 原花青素B2-3,3'-二-O-没食子酸酯 | 3,3'-Digalloylprocyanidin B2 | 124016 |
| 87087-62-5 | - | 3,5-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[(3,4,5-trihydroxybenzoyl)oxymethyl]oxan-2-yl]oxybenzoic acid | 11972354 |
| 13186-19-1 | - | 6-O-Galloylglucose | 128839 |
| 481-72-1 | 芦荟大黄素 | Aloe emodin | 10207 |
| 50488-89-6 | 芦荟大黄素-3-（羟甲基）-O-β-D-葡萄糖苷 | Aloe-emodin-glucoside | 147295 |
| 16198-01-9 | 五乙酸儿茶素酯 | Catechin pentaacetate | 5315742 |
| 4839-60-5 | 大黄酚-1-O-葡萄糖苷 | Chrysophanein | 6324923 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24157255 |
| ALPL | AP-TNAP; APTNAP; HOPS; TNALP; TNAP; TNSALP | 1p36.12 | 25832436 |
| ALPP | ALP; ALPI; IAP; PALP; PLAP; PLAP-1 | 2q37.1 | 25832436 |
| ASRGL1 | ALP; ALP1; CRASH | 11q12.3 | 25832436 |
| ATHS | ALP | 19p13.3-p13.2 | 25832436 |
| ATRNL1 | ALP; bA338L11.1; bA454H24.1 | 10q25.3 | 25832436 |
| BAX | BCL2L4 | 19q13.33 | 30674340 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 30674340 |
| BGLAP | BGP; OC; OCN | 1q22 | 25832436 |
| CASP1 | ICE; IL1BC; P45 | 11q22.3 | 24721152 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Alzheimer's Disease | disease | 30447302 |
| Diabetic Nephropathy | disease | 21195168 |
| Head and Neck Neoplasms | group | 24157255 |
| Inflammation | phenotype | 24721152 |
| leukemia | disease | 27270429 |
| Liver neoplasms | group | 23848338 |
| Nasopharyngeal carcinoma | disease | 31731581 |
| Obesity | disease | 31384536 |
| Osteoporosis | disease | 25832436 |
| Osteoporosis | disease | 27692562 |
