1. 药材主信息
| 中文名称: | 三尖杉 |
| 英文名称: | Fortune Plumyew |
| 拉丁名称: | Cephalotaxus fortunei |
| 使用部位: | branchlet-leaf |
| 功用: | Anticancer. |
| 适用症: | Carcinoma of stomach, carcinoma of rectum, carcinoma of lung, carcinoma of esophagus, lymphatic sarcoma, leukaemia. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 93470-27-0 | (S)-(+)-1-环己乙基异氰酸酯 | (S)-(+)-1-Cyclohexylethyl isocyanate | 40427464 |
| 5876-87-9 | - | 1,11-Dodecadiene | 22170 |
| 49686-55-7 | - | 11-Hydroxycephalotaxine | 285343 |
| 156-81-0 | 2,4-二氨基嘧啶 | 2,4-Diaminopyrimidine | 67431 |
| 36804-95-2 | - | 3(R)-Deoxyharringtonine | 56840949 |
| 24204-36-2 | - | 3-Epi-schelhammericine | 296196 |
| 25499-90-5 | 3-表齐墩果酸 | 3-Epioleanolic acid | 11869658 |
| 84567-08-8 | 4-羟基三尖杉碱 | 4-Hydroxycephalotaxine | 158670 |
| 61203-82-5 | 4-正丁基环己酮 | 4-N-Butylcyclohexanone | 543708 |
| 65725-10-2 | - | 8-Deoxylactucin | 442196 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21871133 |
| AREG | AR; AREGB; CRDGF; SDGF | 4q13.3 | 24520077 |
| BAX | BCL2L4 | 19q13.33 | 31963815 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 21871133 |
| BCL2L1 | BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 | 20q11.21 | 21871133 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 31570787 |
| CAT | - | 11p13 | 29179721 |
| CD274 | B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; hPD-L1 | 9p24.1 | 27378243 |
| CDC37 | P50CDC37 | 19p13.2 | 21871133 |
| CDK4 | CMM3; PSK-J3 | 12q14.1 | 21871133 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 21550230 |
| Blood Pressure | phenotype | 28143892 |
| Constipation | phenotype | 23041323 |
| Epstein-Barr Virus Infections | group | 28056971 |
| Fatty Liver Disease | disease | 22531947 |
| Fibrosis | phenotype | 28143892 |
| Gastrointestinal Neoplasms | group | 24520077 |
| Glucose tolerance test | phenotype | 28490483 |
| Hyperglycemia | disease | 23471488 |
| Inflammation | phenotype | 27374313 |
