1. 药材主信息
| 中文名称: | 破故纸 |
| 英文名称: | fruit of Malaytea scurfpea |
| 拉丁名称: | Fructus Psoraleae Corylifoliae |
| 使用部位: | Psoralea corylifolia L. |
| 功用: | Treatment of impotence, seminal emission, enuresis, frequent urination, aching of the loins and knees with cold sensation, asthma in deficiency syndromes of the kidney, diarrhea occurring before dawn daily. External use for vitiligo and alpecia areata. |
| 适用症: | 1. Corylifolinin ( isobavachalcone ) dilates coronary artery significantly. 2. Promoting phagocytosis of macrophage. 3. Exciting the intestinal smooth muscles in vivo or in vitro, and relaxing the uterus of guinea-pigs in vitro. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 68236-13-5 | 6-异戊二烯基柚皮素 | 6-Prenylnaringenin | 155094 |
| 523-50-2 | 异补骨脂素 | Angelicin | 10658 |
| 480-10-4 | 紫云英苷 | Astragalin | 5282102 |
| 4412-93-5 | ALLOPSORALEN | Bakuchicin | 3083848 |
| 10309-37-2 | 补骨脂酚 | Bakuchiol | 5468522 |
| 28448-85-3 | 补骨脂查尔酮 | Bavachalcone | 6450879 |
| 41743-38-8 | Bavachromene | Bavachromene | 5321800 |
| 775351-91-2 | 8-异戊烯基-7,3',4'-三羟基黄酮 | Corylifol C | 91886689 |
| 53947-92-5 | 补骨脂宁 | Corylin | 5316097 |
| 492-62-6 | - | D-Glucose | 5793 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCA1 | ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1; HPALP1; TGD | 9q31.1 | 26558782 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 24107776 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 24107776 |
| ABCG1 | ABC8; WHITE1 | 21q22.3 | 26558782 |
| ABCG5 | STSL; STSL2 | 2p21 | 24107776 |
| ABCG8 | GBD4; STSL; STSL1 | 2p21 | 24107776 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31534518 |
| APOE | AD2; APO-E; ApoE4; LDLCQ5; LPG | 19q13.32 | 26558782 |
| APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | 21q21.3 | 24107941 |
| BACE1 | ASP2; BACE; HSPC104 | 11q23.3 | 24107941 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Autistic Disorder | disease | 26833134 |
| Body Weight | phenotype | 21557739 |
| Brain Ischemia | disease | 28655710 |
| Carcinogenesis | phenotype | 28588318 |
| Fatty Liver | disease | 21557739 |
| Hypoxia | phenotype | 22743170 |
| Liver diseases | group | 24107776 |
| Liver neoplasms | group | 29749376 |
| Metabolic Diseases | group | 31534518 |
| Obesity | disease | 21557739 |
