1. 药材主信息
| 中文名称: | 老鼠簕 |
| 英文名称: | Hollyleaf Acanthus |
| 拉丁名称: | Acanthus ilicifolius |
| 使用部位: | root or branch-leaf |
| 功用: | To clear heat and resolve toxin, transform phlegm and disinhibit damp, dissipate stasis and relieve pain. |
| 适用症: | Mumps, scrofula, liver spleen enlargement, stomachache, taxation damage in lumbar muscle, phlegm-heat cough asthma, jaundice, white turbidity, acute hepatitis, chronic hepatitis. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 557-61-9 | 1-二十八烷醇 | 1-Octacosanol | 68406 |
| 17359-54-5 | 2,4-二羟基-2H-1,4-苯并噁嗪-3(4H)-酮 | 2,4-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one | 28495 |
| 21637-25-2 | - | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | 51402807 |
| 59-49-4 | 2-苯并恶唑啉酮 | 2-Benzoxazolinone | 6043 |
| 520-36-5 | 芹菜素 | Apigenin | 5280443 |
| 117-39-5 | 槲皮素 | Quercetin | 5280343 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 21445586 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21871133 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 21871133 |
| BCL2L1 | BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 | 20q11.21 | 21871133 |
| CASR | CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1; hCasR | 3q13.33-q21.1 | 21445586 |
| CAT | - | 11p13 | 29179721 |
| CD274 | B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; hPD-L1 | 9p24.1 | 27378243 |
| CDC37 | P50CDC37 | 19p13.2 | 21871133 |
| CDK4 | CMM3; PSK-J3 | 12q14.1 | 21871133 |
| COLQ | CMS5; EAD | 3p25.1 | 28056971 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 21550230 |
| Blood Pressure | phenotype | 28143892 |
| Epstein-Barr Virus Infections | group | 28056971 |
| Fibrosis | phenotype | 28143892 |
| Inflammation | phenotype | 27374313 |
| Liver Neoplasms, Experimental | phenotype | 21445586 |
| Lung Neoplasms | group | 21550230 |
| Multiple Myeloma | disease | 21871133 |
| Neoplasm Metastasis | phenotype | 31182131 |
| Obesity | disease | 27374313 |
