1. 药材主信息
| 中文名称: | 贯众 |
| 英文名称: | root of Chinese Angelica |
| 拉丁名称: | Rhizoma Dryopteris crassirhizomae |
| 使用部位: | Dryopteris crassirhixoma Nakai.;Osmunda japonica Thunb.;Woodwardia unigemmata (Makino) Nakai |
| 功用: | 1. To clear heat and toxic material. For preventing and treating pestilence and seasonal febrile diseases, such as influenza, epidemic cerebrospinal meningitis, mumps, measles, etc., also for viral pneumonia. 2. To cool the blood nad stop bleeding. For profuse uterine bleeding due to blood-heat, hematemesis, epistaxis, hemafacia, eruptive diseases, etc. |
| 适用症: | Antivirotic and bacteriostatic. 2. Parasiticidal effect on hookworm, roundworm and whipworm, etc. in human, and its component filmarone, on tapeworm. 3. Its decoction shortens the blood clotting time in rabbits. 4. Its extract exerts an abortive effect. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 21637-25-2 | - | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | 51402807 |
| 474-63-5 | 5,24(28)-Cholestadien-24-methylen-3beta-ol | 24-Methylenecholesterol | 92113 |
| 58409-52-2 | - | Albaspidin | 42738 |
| 480-10-4 | 紫云英苷 | Astragalin | 5282102 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 885044-12-2 | Farrerol 7-O-glucoside | Cyrtopterin | 42607898 |
| 2034-69-7 | 西瑞香素 | Daphnoretin | 5281406 |
| 1615-91-4 | - | Diploptene | 92155 |
| 12777-70-7 | 绵马贯众素ABBA | Dryocrassin ABBA | 3082025 |
| 3604-87-3 | - | Ecdysone | 19212 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 21445586 |
| CASR | CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1; hCasR | 3q13.33-q21.1 | 21445586 |
| FOXO1 | FKH1; FKHR; FOXO1A | 13q14.11 | 31063760 |
| FOXO3 | AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A | 6q21 | 31063760 |
| HDAC8 | CDA07; CDLS5; HD8; HDACL1; KDAC8; MRXS6; RPD3; WTS | Xq13.1 | 28528906 |
| LAS1L | Las1; Las1-like; WTS; dJ475B7.2 | Xq12 | 28528906 |
| LATS1 | WARTS; wts | 6q25.1 | 28528906 |
| MAP3K5 | ASK1; MAPKKK5; MEKK5 | 6q23.3 | 31063760 |
| MAPK8 | JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c | 10q11.22 | 31063760 |
| SLCO1A2 | OATP; OATP-A; OATP1A2; SLC21A3 | 12p12.1 | 31928869 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Carcinogenesis | phenotype | 30120247 |
| Liver Neoplasms, Experimental | phenotype | 21445586 |
| Neoplasms | group | 30120247 |
