1. 药材主信息
| 中文名称: | 关木通 |
| 英文名称: | Manchurian Dutchmanspipe |
| 拉丁名称: | Aristolochia manshuriensis |
| 使用部位: | stem |
| 功用: | To clear heart fire, disinhibit urine, free menstruation and milk. |
| 适用症: | Mouth sore, tongue sores, vexation and reddish urine, edema, heat strangury with inhibited pain, leukorrhea, amenorrhea and scant milk, damp-heat impediment pain. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 53948-07-5 | Aristolactam AII | Aristolactam AII | 148657 |
| 55610-00-9 | - | Aristolactam II | 148745 |
| 313-67-7 | 马兜铃酸A | Aristolochic acid | 2236 |
| 1169-60-4 | - | Aristolochic acid I methyl ester | 96709 |
| 475-80-9 | 马兜铃酸B | Aristolochic acid II | 108168 |
| 13395-02-3 | 马兜铃内酰胺I | Aristololactam | 96710 |
| 84014-70-0 | - | Aristoloside | 128576 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 17184-21-3 | 常春藤皂苷元-3-O-α-L-吡喃阿拉伯糖苷 | Cauloside A | 441928 |
| 17184-21-3 | 常春藤皂苷元-3-O-α-L-吡喃阿拉伯糖苷 | Cauloside A | 441928 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 24107776 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 24107776 |
| ABCG5 | STSL; STSL2 | 2p21 | 24107776 |
| ABCG8 | GBD4; STSL; STSL1 | 2p21 | 24107776 |
| APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | 21q21.3 | 24107941 |
| BACE1 | ASP2; BACE; HSPC104 | 11q23.3 | 24107941 |
| CEBPA | C/EBP-alpha; CEBP | 19q13.11 | 29141998 |
| NR1H2 | LXR-b; LXRB; NER; NER-I; RIP15; UNR | 19q13.33 | 24107776 |
| NR1H3 | LXR-a; LXRA; RLD-1 | 11p11.2 | 24107776 |
| NR1H4 | BAR; FXR; HRR-1; HRR1; PFIC5; RIP14 | 12q23.1 | 24107776 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Liver diseases | group | 24107776 |
| Obesity | disease | 29141998 |
