1. 药材主信息
| 中文名称: | 大独活 |
| 英文名称: | root of Laxflower Cowparsnip |
| 拉丁名称: | Radix Heraclei maximi |
| 使用部位: | Heracleum maximum Bartram |
| 功用: | Treatment of rheumatic arthritis with pain in the lower back and knees, headache due to attack of cold on the Shaoyin Channel characterized by association of headache with precordial pain and cold legs. |
| 适用症: | Treatment of rheumatic arthritis with pain in the lower back and knees, headache due to attack of cold on the Shaoyin Channel characterized by association of headache with precordial pain and cold legs. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 91-20-3 | 萘 | Naphthalene | 931 |
| 484-12-8 | 蛇床子素 | Osthol | 10228 |
| 515-13-9 | β-榄香烯 | β-Elemene | 6918391 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| EDN1 | ARCND3; ET1; HDLCQ7; PPET1; QME | 6p24.1 | 26231226 |
| IL13 | IL-13; P600 | 5q31.1 | 28782757 |
| IL5 | EDF; IL-5; TRF | 5q31.1 | 28782757 |
| IL6 | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 | 7p15.3 | 26337552 |
| NFE2L2 | HEBP1; IMDDHH; NRF2; Nrf-2 | 2q31.2 | 24858719 |
| NOTCH1 | AOS5; AOVD1; TAN1; hN1 | 9q34.3 | 28823624 |
| PTGS2 | COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 | 1q31.1 | 24858719 |
| STAT3 | ADMIO; ADMIO1; APRF; HIES | 17q21.2 | 30577812 |
| TGFB1 | CED; DPD1; IBDIMDE; LAP; TGF-beta1; TGFB; TGFbeta | 19q13.2 | 26231226 |
| TNF | DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F | 6p21.33 | 26231226 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Allergic asthma | disease | 28782757 |
| Brain Edema | phenotype | 26337552 |
| Encephalitis | disease | 26337552 |
| Inflammation | phenotype | 24858719 |
| Liver Cirrhosis | disease | 26231226 |
| Proteinuria | phenotype | 24858719 |
| Triple Negative Breast Neoplasms | disease | 30577812 |
