1. 药材主信息
| 中文名称: | 蟾酥 |
| 英文名称: | Toad Skin Secretion Cake |
| 拉丁名称: | Bufo bufo gargarizans, Bufo melanostictus |
| 使用部位: | dried secretion of skin glands |
| 功用: | To resolve toxin, relieve pain, open orifices and arouse spirit. |
| 适用症: | Welling abscess and flat abscess with clove sores, swelling pain in throat, summerheat stroke with vomiting and diarrhea, abdominal pain and clouded spirit, local anesthesia. |
| 毒副作用: | Toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 434-16-2 | 7-脱氢胆固醇 | 7-Dehydrocholesterol | 439423 |
| 464-74-4 | 沙蟾毒精 | Arenobufagin | 12305198 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 29565-35-3 | - | Bufadienolide | 46173848 |
| 465-19-0 | - | Bufogenin B | 12358889 |
| 471-95-4 | 蟾毒它灵 | Bufotalin | 12302120 |
| 487-91-2 | 蟾蜍特尼定 | Bufotenidine | 3083591 |
| 487-93-4 | 蟾蜍色胺 | Bufotenine | 10257 |
| 20972-07-0 | - | Campesteryl Ferulate | 15056832 |
| 57-88-5 | 胆固醇 | Cholesterol | 5997 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 28492559 |
| AQP4 | MIWC; WCH4 | 18q11.2 | 31746080 |
| ATG5 | APG5; APG5-LIKE; APG5L; ASP; SCAR25; hAPG5 | 6q21 | 21763418 |
| ATP1A1 | CMT2DD; HOMGSMR2 | 1p13.1 | 30739221 |
| ATP1A3 | AHC2; ATP1A1; CAPOS; DYT12; RDP | 19q13.2 | 30739221 |
| ATP1A3 | AHC2; ATP1A1; CAPOS; DYT12; RDP | 19q13.2 | 31746080 |
| ATP1A4 | ATP1A1; ATP1AL2 | 1q23.2 | 30739221 |
| BAX | BCL2L4 | 19q13.33 | 24561580 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 24561580 |
| BECN1 | ATG6; VPS30; beclin1 | 17q21.31 | 21763418 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Autoimmune Diseases | group | 21076398 |
| Colonic Neoplasms | group | 21763418 |
| Glioblastoma | disease | 31746080 |
| Glioma | disease | 30739221 |
| Lung Neoplasms | group | 23352980 |
| melanoma | disease | 24561580 |
| Multiple Myeloma | disease | 28492559 |
| Nasopharyngeal carcinoma | disease | 31754475 |
| Nasopharyngeal carcinoma | disease | 31594754 |
| Neuralgia | phenotype | 28098360 |
