1. 药材主信息
| 中文名称: | 小檗 |
| 英文名称: | Amur Barberry |
| 拉丁名称: | Berberis amurensis |
| 使用部位: | root and branchlet |
| 功用: | To clear heat and dry damp, resolve toxin. |
| 适用症: | Enteritis, dysentery, chronic cholecystitis, acute hepatitis, chronic hepatitis, bacillary dysentery, infection of upper respiratory tract, urinary tract infection, leukopenic complications of carcinoma, innominate toxin swelling, erysipelas, eczema, red eyes, mouth sore. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 478-61-5 | 小檗胺 | Berbamine | 275182 |
| 485-18-7 | - | Berbamunine | 440585 |
| 2086-83-1 | 小檗碱 | Berberine | 2353 |
| 3621-36-1 | 非洲防己碱 | Columbamine | 72310 |
| 5058-13-9 | 二氢欧山芹醇当归酸酯 | Columbianadin | 6436246 |
| 3621-38-3 | 药根碱 | Jatrorrhizine | 72323 |
| 476-45-9 | - | Javanicin | 10149 |
| 2141-09-5 | 木兰花碱 | Magnoflorine | 73337 |
| 549-17-7 | - | Oxyayanin A | 5281676 |
| 549-21-3 | 氧化小檗碱 | Oxyberberine | 11066 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ANXA5 | ANX5; ENX2; HEL-S-7; PP4; RPRGL3 | 4q27 | 25682924 |
| BAX | BCL2L4 | 19q13.33 | 25682924 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 21496227 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 28990249 |
| CCNA1 | CT146 | 13q13.3 | 25682924 |
| CCNB1 | CCNB | 5q13.2 | 25682924 |
| CDK1 | CDC2; CDC28A; P34CDC2 | 10q21.2 | 25682924 |
| CDK4 | CMM3; PSK-J3 | 12q14.1 | 25682924 |
| CDKN1A | CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1 | 6p21.2 | 25682924 |
| DNM1L | DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV; OPA5 | 12p11.21 | 31037132 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Carcinoma, Ovarian Epithelial | disease | 28990249 |
| Diabetes Mellitus, Experimental | disease | 27067643 |
| Diabetes Mellitus, Experimental | disease | 20304443 |
| Glucose tolerance test | phenotype | 20304443 |
| Hyperglycemia | disease | 27067643 |
| Insulin Resistance | phenotype | 22019891 |
| Insulin Resistance | phenotype | 20304443 |
| Left Ventricular Hypertrophy | disease | 31371114 |
| Neoplasms, Glandular and Epithelial | group | 28990249 |
| ovarian neoplasm | disease | 28990249 |
