1. 药材主信息
| 中文名称: | 天仙子 |
| 英文名称: | Henbane Seed |
| 拉丁名称: | Semen Hyoscyami |
| 使用部位: | - |
| 功用: | To relieve spasm and pain, and to cause tranquilization. |
| 适用症: | 1. Antisudorific, saliva antisecretory and mydriatic.2. Relaxing the smooth muscles.3. Increasing heart rate and exciting the respiratory center. |
| 毒副作用: | Slightly Toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 41059-79-4 | - | (2S,3R,4S,5S,6R)-2-[(2R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(2R,7S,9S,13S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | 53486208 |
| 13710-70-8 | 印度榅桲素 | 2-(2-Hydroxypropan-2-yl)-2,3-dihydrofuro[3,2-g]chromen-7-one | 604512 |
| 185020-38-6 | (+)-Nyasol | 4-[(1Z,3S)-3-(4-hydroxyphenyl)penta-1,4-dienyl]phenol | 5281830 |
| 51-55-8 | 阿托品 | Atropine | 174174 |
| 51-55-8 | 阿托品 | Atropine | 174174 |
| 62-49-7 | 2-羟基-N,N,N-三甲基乙铵 | Choline | 305 |
| 163047-21-0 | 知母皂苷I | CID 101672279 | 101672279 |
| 163047-21-0 | 知母皂苷I | CID 101672279 | 101672279 |
| 933054-33-2 | Monomethyl lithospermate | CID 95224420 | 95224420 |
| 39941-51-0 | - | Degalactotigonin | 162401 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| CEBPA | C/EBP-alpha; CEBP | 19q13.11 | 30472463 |
| CHRNA7 | CHRNA7-2; NACHRA7 | 15q13.3 | 31560162 |
| DGKD | DGK-delta; DGKdelta; dgkd-2 | 2q37.1 | 28707095 |
| PPARG | CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma | 3p25.2 | 30472463 |
| PTGS2 | COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2 | 1q31.1 | 31757048 |
| SAE1 | AOS1; HSPC140; SUA1; UBLE1A | 19q13.32 | 25263445 |
| SIGMAR1 | ALS16; DSMA2; OPRS1; SIG-1R; SR-BP; SR-BP1; SRBP; hSigmaR1; sigma1R | 9p13.3 | 31560162 |
| SMAD2 | JV18; JV18-1; MADH2; MADR2; hMAD-2; hSMAD2 | 18q21.1 | 31970286 |
| SMAD3 | HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3 | 15q22.33 | 31970286 |
| SMAD4 | DPC4; JIP; MADH4; MYHRS | 18q21.2 | 31970286 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Aging | phenotype | 24932939 |
| Alzheimer's Disease | disease | 31560162 |
| Diabetes | disease | 28707095 |
| Down Syndrome | disease | 24932939 |
| Hyperglycemia | disease | 28707095 |
| Inflammation | phenotype | 26850942 |
| Obesity | disease | 30472463 |
| Trisomy | group | 24932939 |
