科华智慧(深圳)创新药物研发有限公司     西北农林科技大学深圳研究院    联合开发

1. 药材主信息

中文名称: 蒲公英
英文名称: Mongolian Dandelion
拉丁名称: Taraxacum mongolicum
使用部位: aerial parts
功用: To clear heat and resolve toxin, dissipate binds and disperse swelling, disinhibit urine and free strangury.
适用症: Epidemic parotitis, infection of upper respiratory tract, tonsillitis, laryngitis, sore pharynx, mastitis, hepatitis, swelling toxin of clove sore, mammary welling abscess, scrofula, red eyes, pulmonary welling abscess, damp-heat jaundice, heat strangury with inhibited pain.
毒副作用: -

2. 相关成分

CAS号 中文名称 英文名称 参考文献
501-97-3 对羟基苯丙酸 3-(4-Hydroxyphenyl)propionic acid 10394
10180-88-8 hydroxyachillin Austricin 6713966
65-85-0 苯甲酸 Benzoic Acid 243
18968-14-4 - beta-D-galactopyranuronic acid 441476
75911-14-7 Taraxinic acid β-D-glucopyranosyl ester beta-D-Glucopyranose, 1-[(3aS,6Z,10E,11aR)-2,3,3a,4,5,8,9,11a-octahydro-10-methyl-3-methylene-2-oxocyclodeca[b]furan-6-carboxylate] 95392279
83-46-5 β-谷甾醇 Beta-Sitosterol 222284
331-39-5 咖啡酸 Caffeic Acid 689043
3843-74-1 咖啡酸甲酯 Caffeic acid methyl ester 689075
7440-70-2 - Calcium 5460341
6537-80-0 菊苣酸 Chicoric acid 5281764

3. 相关靶点

基因靶点 基因别名 靶点位置 参考文献
CASP3 CPP32; CPP32B; SCA-1 4q35.1 27756327
CASP8 ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 2q33.1 27756327
CASP9 APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 1p36.21 27756327
CAT - 11p13 24559844
CHRNA7 CHRNA7-2; NACHRA7 15q13.3 31560162
CXCL1 FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1 4q13.3 25281414
CYP2E1 CPE1; CYP2E; P450-J; P450C2E 10q26.3 24559844
DDIT3 AltDDIT3; C/EBPzeta; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153 12q13.3 28780078
DGKD DGK-delta; DGKdelta; dgkd-2 2q37.1 28707095
ETFDH ETFQO; MADD 4q32.1 30232818

4. 相关疾病

疾病名称 疾病类型 参考文献
Adenoma group 21693628
Aging phenotype 24932939
Alzheimer's Disease disease 31560162
Body Weight phenotype 24559844
Brain Ischemia disease 30014516
Brain Ischemia disease 24884571
Colitis disease 25281414
Colorectal Neoplasms group 21693628
Diabetes disease 28049156
Diabetes disease 28707095