1. 药材主信息
| 中文名称: | 牡丹皮 |
| 英文名称: | Tree Peony Bark |
| 拉丁名称: | Cortex Moutan |
| 使用部位: | root cortex |
| 功用: | To remove heat from blood, to activate blood circulation and eliminate blood stasis. |
| 适用症: | Appendicitis, dysentery, hypertension, allergic rhinitis, warm heat disease with fever, macular eruption, blood ejection, spontaneous external bleeding, steaming bone tidal fever due to yin vacuity, amenorrhea due to blood stasis, dysmenorrhea, concretion and conglomeration, swelling toxin of welling abscess and sore, painful wound from knocks and falls, wind-damp-heat impediment. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 231280-71-0 | 牡丹皮苷H | - | 71457654 |
| 7785-70-8 | (1R)-(+)-alpha-蒎烯 | (+)-alpha-Pinene | 82227 |
| 507-70-0 | - | (+)-Isoborneol | 6973640 |
| 3173-02-2 | - | (+)-Oxypeucedanin | 928465 |
| 5794-04-7 | - | (-)-Camphene | 440966 |
| 52842-47-4 | - | (-)-Columbianetin | 442104 |
| 77982-63-9 | - | (1S,5R)-6,6-dimethylnorpinan-2-one | 157139 |
| 708-53-2 | 2,3-二羟基-4-甲氧基苯乙酮水合物 | 1-(2,3-Dihydroxy-4-methoxyphenyl)ethanone | 12820 |
| 6100-74-9 | 4-甲氧基-3-羟基苯乙酮 | 1-(3-Hydroxy-4-methoxyphenyl)ethanone | 95693 |
| 21637-25-2 | - | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | 51402807 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 21445586 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31406198 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27017346 |
| CASR | CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1; hCasR | 3q13.33-q21.1 | 21445586 |
| CDH1 | Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO | 16q22.1 | 27017346 |
| CEBPA | C/EBP-alpha; CEBP | 19q13.11 | 29141998 |
| EDN1 | ARCND3; ET1; HDLCQ7; PPET1; QME | 6p24.1 | 26231226 |
| GSK3B | - | 3q13.33 | 21039417 |
| HSPA4 | APG-2; HEL-S-5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY | 5q31.1 | 29017971 |
| ICAM1 | BB2; CD54; P3.58 | 19p13.2 | 21542832 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Allergic asthma | disease | 28782757 |
| Alzheimer's Disease | disease | 30447302 |
| Atherosclerosis | disease | 27017346 |
| Brain Edema | phenotype | 26337552 |
| Encephalitis | disease | 26337552 |
| Encephalitis | disease | 30975172 |
| Hyperalgesia | phenotype | 30975172 |
| Hyperalgesia | phenotype | 29017971 |
| Inflammation | phenotype | 24858719 |
| Inflammation | phenotype | 29017971 |
