1. 药材主信息
| 中文名称: | 狼毒 |
| 英文名称: | Chinese Stellera |
| 拉丁名称: | Stellera chamaejasme |
| 使用部位: | root |
| 功用: | To expel water and dispel phlegm, break accumulation and kill worms. |
| 适用症: | Edema distention fullness, a ccumulation from phlegm, food accumulation, worm accumulation, pain in heart and abdomen, chronic trachitis, cough, asthma, scab and lichen, hemorrhoids and fistulas, scrofula, bone tuberculosis, epididymis tubercle. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 7785-70-8 | (1R)-(+)-alpha-蒎烯 | (+)-alpha-Pinene | 82227 |
| 1620921-68-7 | 4',4'''-Di-O-methylisochamaejasmin | Chamaejasmenin A | 71728343 |
| 89595-71-1 | 狼毒宁B | Chamaejasmenin B | 21676273 |
| 89595-70-0 | Chamaejasmenin C | Chamaejasmenin C | 496376 |
| 104-54-1 | 肉桂醇 | Cinnamyl alcohol | 5315892 |
| 486-35-1 | 瑞香素;祖师麻甲素 | Daphnetin | 5280569 |
| 20853-56-9 | Daphnetin 8-O-glucoside | Daphnetin-8-glucoside | 5316301 |
| 3749-38-0 | - | Daphnoretin methyl ether | 5318544 |
| 112-40-3 | 十二烷 | Dodecane | 8182 |
| 482-48-4 | 异佛手柑内酯 | Isobergapten | 68082 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| BAX | BCL2L4 | 19q13.33 | 28188924 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 28188924 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 28188924 |
| CRYZ | - | 1p31.1 | 28188924 |
| HMOX1 | HMOX1D; HO-1; HSP32; bK286B10 | 22q12.3 | 28188924 |
| KEAP1 | INrf2; KLHL19 | 19p13.2 | 28188924 |
| MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | 22q11.22 | 28188924 |
| MAPK8 | JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c | 10q11.22 | 28188924 |
| NFE2L2 | HEBP1; IMDDHH; NRF2; Nrf-2 | 2q31.2 | 28188924 |
| NLRP3 | AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1 | 1q44 | 28188924 |
