1. 药材主信息
| 中文名称: | 莨菪子 |
| 英文名称: | Black Henbane Seed |
| 拉丁名称: | Hyoscyamus niger |
| 使用部位: | ripe seed |
| 功用: | To resolve spasm and relieve pain, quiet heart and settle epilepsy. |
| 适用症: | Pain in stomach duct and abdomen, wind-damp impediment pain, decayed toothache due to wind, painful wound from knocks and falls, incessant asthma and cough, prolapse of rectum due to diarrhea, mania and withdrawal, fright epilepsy, swelling toxin of welling abscess and sore. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 101-31-5 | - | (S)-((1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate | 6931560 |
| 51-55-8 | 阿托品 | Atropine | 174174 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 454-14-8 | 红古豆碱 | Cuscohygrine | 1201543 |
| 529-92-0 | - | Cusparine | 442893 |
| 80510-06-1 | 克罗酰胺 | Grossamide | 101262727 |
| 544-63-8 | 肉豆蔻酸 | Myristic Acid | 11005 |
| 66648-43-9 | N-反式-阿魏酰基酪胺 | N-Trans-feruloyltramine | 5280537 |
| 112-80-1 | 油酸 | Oleic Acid | 445639 |
| 57-10-3 | 棕榈酸 | Palmitic Acid | 985 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| CEBPA | C/EBP-alpha; CEBP | 19q13.11 | 29141998 |
| CXCL1 | FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1 | 4q13.3 | 25281414 |
| DGKD | DGK-delta; DGKdelta; dgkd-2 | 2q37.1 | 28707095 |
| IFNG | IFG; IFI | 12q15 | 25281414 |
| IL1B | IL-1; IL1-BETA; IL1F2; IL1beta | 2q14.1 | 25281414 |
| MPO | - | 17q22 | 25281414 |
| PPARG | CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma | 3p25.2 | 29141998 |
| PPARGC1A | LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1 | 4p15.2 | 28049156 |
| S100A8 | 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MIF; MRP8; NIF; P8 | 1q21.3 | 25281414 |
| SIRT1 | SIR2; SIR2L1; SIR2alpha | 10q21.3 | 28049156 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Colitis | disease | 25281414 |
| Diabetes | disease | 28049156 |
| Diabetes | disease | 28707095 |
| Diabetes Mellitus, Experimental | disease | 26185015 |
| Diabetic Cardiomyopathies | disease | 26185015 |
| Hyperglycemia | disease | 28707095 |
| Obesity | disease | 28049156 |
| Obesity | disease | 29141998 |
| Ventricular Remodeling | phenotype | 26185015 |
