1. 药材主信息
| 中文名称: | 苦玄参 |
| 英文名称: | Common Bitterfigwort |
| 拉丁名称: | Picria felterrae |
| 使用部位: | whole herb |
| 功用: | To clear heat and resolve toxin, disperse swelling and relieve pain. |
| 适用症: | Wind-heat common cold, swelling pain in throat, mumps, swollen boil, diarrhea and dysentery, hemorrhoids, eczema, poisonous snake bites, knocks and falls. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 474-58-8 | 刺五加苷A(胡萝卜苷） | Sitogluside | 5742590 |
| 61276-17-3 | 毛蕊花糖苷;麦角甾苷；类叶升麻苷 | Verbascoside | 5281800 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 29555592 |
| FGFR1 | BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD; bFGF-R-1 | 8p11.23 | 23414442 |
| FYN | SLK; SYN; p59-FYN | 6q21 | 29555592 |
| GSK3B | - | 3q13.33 | 29555592 |
| HMGB1 | HMG-1; HMG1; HMG3; SBP-1 | 13q12.3 | 23414442 |
| HMOX1 | HMOX1D; HO-1; HSP32; bK286B10 | 22q12.3 | 25936352 |
| MAP3K14 | FTDCR1B; HS; HSNIK; NIK | 17q21.31 | 29505920 |
| MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | 22q11.22 | 28923043 |
| MAPK14 | CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA | 6p21.31 | 28923043 |
| NFE2L2 | HEBP1; IMDDHH; NRF2; Nrf-2 | 2q31.2 | 25936352 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Alzheimer's Disease | disease | 29555592 |
| Brain Ischemia | disease | 23414442 |
| Cardiac fibrosis | disease | 29367637 |
| Diabetes Mellitus, Experimental | disease | 23414442 |
| Fibrosis | phenotype | 29367637 |
| Fibrosis | phenotype | 24494798 |
| Inflammation | phenotype | 28923043 |
| Melanoma, Experimental | disease | 29505920 |
| Polycystic Kidney, Autosomal Dominant | disease | 24494798 |
