1. 药材主信息
| 中文名称: | 海南粗榧 |
| 英文名称: | Hainan Plumyew |
| 拉丁名称: | Cephalotaxus hainanensis [Syn. Cephalotaxus mannii |
| 使用部位: | branchlet and bark |
| 功用: | Anticancer. |
| 适用症: | Carcinoma. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 36804-95-2 | - | 3(R)-Deoxyharringtonine | 56840949 |
| 24204-36-2 | - | 3-Epi-schelhammericine | 296196 |
| 65725-10-2 | - | 8-Deoxylactucin | 442196 |
| 71610-00-9 | - | Cephalomannine, analytical standard | 5281819 |
| 41787-72-8 | - | Hallactone A | 442035 |
| 64761-48-4 | - | Harringtonolide | 56841078 |
| 1805-85-2 | - | Hasubanonine | 442246 |
| 5843-65-2 | 去甲乌药碱 | Higenamine | 114840 |
| 477-20-3 | - | Homolycorine | 160473 |
| 26833-86-3 | - | Isoharringtonine | 73492 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| Atat1 | 0610011P08Rik; 2610008K08Rik; 2610110G12Rik; 3110080J08Rik; MEC-17; Mec17; TAT | 17|17 B1 | 28968698 |
| AURKA | AIK; ARK1; AURA; BTAK; PPP1R47; STK15; STK6; STK7 | 20q13.2 | 23348568 |
| BAX | BCL2L4 | 19q13.33 | 24080340 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 23681233 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 28589243 |
| BCL2L1 | BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 | 20q11.21 | 23681233 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 28589243 |
| CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | 1p36.21 | 28589243 |
| CCL2 | GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF | 17q12 | 23726937 |
| CCR2 | CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R | 3p21.31 | 23726937 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Carcinogenesis | phenotype | 28589243 |
| Carcinogenesis | phenotype | 25827073 |
| Carcinoma, Transitional Cell | disease | 20682548 |
| Fibrosis | phenotype | 21984124 |
| Hyperalgesia | phenotype | 21145656 |
| Liver neoplasms | group | 29748662 |
| Longevity | phenotype | 26913604 |
| Lung Neoplasms | group | 31779616 |
| Lung Neoplasms | group | 28991240 |
| Lung Neoplasms | group | 28589243 |
