1. 药材主信息
| 中文名称: | 功劳木 |
| 英文名称: | Stem of Leatherleaf Mahonia |
| 拉丁名称: | Caulis Mahoniae |
| 使用部位: | - |
| 功用: | To remove dimp-heat, quench fire, and counteract toxicity. |
| 适用症: | Berberine is the main active component with an action similar to Rhizoma Coptidis. Another active component, isotetrandrine, is an anticarcinogenic agent. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 506-30-9 | 花生酸 | - | 10467 |
| 26137-48-4 | - | 1-Isotetrandrine | 5351212 |
| 26137-48-4 | - | 1-Isotetrandrine | 5351212 |
| 27400-77-7 | - | 1-Nonadecene | 29075 |
| 4669-02-7 | 14-甲基十五烷酸 | 14-Methylpentadecanoic acid | 36247 |
| 96-76-4 | 2,4-二叔丁基酚 | 2,4-Di-tert-butylphenol | 7311 |
| 719-22-2 | 2,6-二叔丁基苯醌 | 2,6-Di-tert-butyl-P-benzoquinone | 12867 |
| 1560-88-9 | - | 2-Methyloctadecane | 15264 |
| 642-71-7 | 3,4,5-三甲氧基苯酚 | 3,4,5-Trimethoxyphenol | 69505 |
| 21391-99-1 | - | alpha-Calacorene | 12302243 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AGT | ANHU; SERPINA8; hFLT1 | 1q42.2 | 21844078 |
| ANXA5 | ANX5; ENX2; HEL-S-7; PP4; RPRGL3 | 4q27 | 25682924 |
| BAX | BCL2L4 | 19q13.33 | 25682924 |
| CASP1 | ICE; IL1BC; P45 | 11q22.3 | 31336157 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 21496227 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 28990249 |
| CCNA1 | CT146 | 13q13.3 | 25682924 |
| CCNB1 | CCNB | 5q13.2 | 25682924 |
| CDK1 | CDC2; CDC28A; P34CDC2 | 10q21.2 | 25682924 |
| CDK4 | CMM3; PSK-J3 | 12q14.1 | 25682924 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Carcinoma, Ovarian Epithelial | disease | 28990249 |
| Diabetes | disease | 28707095 |
| Diabetes Mellitus, Experimental | disease | 27067643 |
| Diabetes Mellitus, Experimental | disease | 20304443 |
| Glucose tolerance test | phenotype | 20304443 |
| Hyperglycemia | disease | 23471488 |
| Hyperglycemia | disease | 28707095 |
| Hyperglycemia | disease | 27067643 |
| Insulin Resistance | phenotype | 22019891 |
| Insulin Resistance | phenotype | 20304443 |
