1. 药材主信息
| 中文名称: | 大蓟 |
| 英文名称: | all-grass of Thistle |
| 拉丁名称: | Herba Cirsii Japonici;Radix Cirsii Japonici;Herba |
| 使用部位: | Cirsium japonici DC. |
| 功用: | Treatment of epistaxis, spitting of blood, hematuria, hematochezia, abnormal uterine bleeding, traumatic bleeding, carbuncles and sores. |
| 适用症: | 1. Its decoction can lower blood pressure2. Inhibiting the growth of (a)-streptococcus3. Shortening the bleeding time.4. Anti-inflammatory5. Diuretic. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 22339-23-7 | - | (+)-Calamenene | 11298625 |
| 19870-46-3 | 1,5-二咖啡酰奎宁酸 | 1,3-Dicaffeoylquinic acid | 6474640 |
| 6765-39-5 | 1-十七碳烯 | 1-Heptadecene | 23217 |
| 13360-61-7 | 1-十五碳烯 | 1-Pentadecene | 25913 |
| 16290-50-9 | - | 5,7-Dimethoxy-4'-hydroxyflavone | 161172 |
| 480-44-4 | 金合欢素;刺槐素 | Acacetin | 5280442 |
| 469-61-4 | alpha-柏木烯 | alpha-Cedrene | 6431015 |
| 5951-67-7 | - | alpha-Elemene | 80048 |
| 520-36-5 | 芹菜素 | Apigenin | 5280443 |
| 523-47-7 | - | beta-Cadinene | 10657 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 24107776 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 24107776 |
| ABCG5 | STSL; STSL2 | 2p21 | 24107776 |
| ABCG8 | GBD4; STSL; STSL1 | 2p21 | 24107776 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21871133 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 30825187 |
| APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | 21q21.3 | 24107941 |
| BACE1 | ASP2; BACE; HSPC104 | 11q23.3 | 24107941 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 21871133 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 27735939 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 21550230 |
| Atrial Fibrillation | disease | 21906601 |
| Blood Pressure | phenotype | 28143892 |
| Epstein-Barr Virus Infections | group | 28056971 |
| Fibrosis | phenotype | 28143892 |
| Inflammation | phenotype | 27374313 |
| Liver diseases | group | 24107776 |
| Lung Neoplasms | group | 21550230 |
| Multiple Myeloma | disease | 21871133 |
| Neoplasm Invasiveness | phenotype | 27735939 |
