1. 药材主信息
| 中文名称: | 穿心莲 |
| 英文名称: | all-grass of Common Androgrphis |
| 拉丁名称: | Herba andrographitis |
| 使用部位: | dried aerial parts |
| 功用: | 1. To clear heat and release toxins; 2. To dry dampness |
| 适用症: | Infection of upper respiratory tract, fever, wind-heat common cold, bacillary dysentery, diarrhea, tonsillitis, pneumonia, tuberculosis, lung heat cough, pulmonary welling abscess, postlithotripsy urinary tract infection, warm disease fever, pertussis, swelling pain in throat, damp-heat jaundice, strangury syndrome, erysipelas, sore and welling abscess, eczema, poisonous snake bite. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 42895-58-9 | 脱水穿心莲内酯 | 14-Deoxy-11,12-didehydroandrographolide | 5708351 |
| 4176-97-0 | 14-去氧穿心莲内酯 | 14-Deoxyandrographolide | 11624161 |
| 21637-25-2 | - | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | 51402807 |
| 1244-78-6 | 槲皮素-3',4',5,7-四甲醚 | 3-Hydroxy-3',4',5,7-tetramethoxyflavone | 97142 |
| 3570-62-5 | 7-O-甲基汉黄芩素 | 5-Hydroxy-7,8-dimethoxyflavone | 188316 |
| 3570-62-5 | 7-O-甲基汉黄芩素 | 5-Hydroxy-7,8-dimethoxyflavone | 188316 |
| 87733-81-1 | - | 7,3'-Dihydroxy-4'-methoxy-8-methylflavan | 442358 |
| 82209-74-3 | 新穿心莲内酯苷元 | Andrograpanin | 11666871 |
| 113963-37-4 | 穿心莲黄酮苷A | Andrographidin A | 13963762 |
| 1165-40-8 | - | Andrographin | 5318506 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 29235094 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 29235094 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 21445586 |
| ACACA | ACAC; ACACAD; ACC; ACC1; ACCA | 17q12 | 30630510 |
| ADAMTS4 | ADAMTS-2; ADAMTS-4; ADMP-1 | 1q23.3 | 28237856 |
| ADIPOQ | ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28 | 3q27.3 | 23623334 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21871133 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 25260383 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 20840540 |
| BAX | BCL2L4 | 19q13.33 | 25260383 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 21550230 |
| Adenocarcinoma | group | 22342517 |
| Alzheimer's Disease | disease | 30447302 |
| Blood Pressure | phenotype | 28143892 |
| Body Weight | phenotype | 23623334 |
| Brain Neoplasms | group | 20883786 |
| Cerebellar Neoplasms | group | 20883786 |
| Cholestasis | disease | 29235094 |
| Colorectal Neoplasms | group | 24901054 |
| Dyslipidemias | group | 23623334 |
