1. 药材主信息
| 中文名称: | 川黄连 |
| 英文名称: | rhizome of Chinese Goldthread |
| 拉丁名称: | Rhizoma Coptidis |
| 使用部位: | Coptis chinensis Franch.;Coptis deltoidea C. Y. Cheng et Hsiao.;Coptis teeta Wall. |
| 功用: | Treatment of attack of damp-heat manifested by stuffiness and fullness sensation in the abdomen, or causing acute dysentery of jaundice, high fever accompained by impairment of conciousness, fidgetness and insomnia due to exuberant fire, spitting of blood and epistaxis caused by heat in the blood, inflammation of the eye, acid regurgitation, toothache, diabetes, carbuncles and sores, external use for eczema and other skin diseases with exudation, purulent discharge from the ear.Rhizoma Coptidis (processed with wine) Inflammation of the eye, ulcers in the mouth.Rhizoma Coptidis (processed with ginger) Stuffiness and fullness sensation in the abdomen with nausea and vomiting caused by damp-heat in combination with cold. |
| 适用症: | Its chief component is berberine. 1. Possessing broad-spectrum antibacterial and antiprotozoal effects. 2. Intravenous injection or oral administration of berberine exerts a hypotensive effect on experimental animals. 3. Small dosage of berberine enhances the action of acetylcholine on animals' hearts in vitro, while large dosage counteracts it. 4. Relaxing the smooth muscles of blood vessels and stimulating those of uterus, urinary bladderl bronchus and gastrointestines. 5. Promoting bile secretion. 6. Berberine inhibits the cellular growht of ascitic cancer and lymphoma. |
| 毒副作用: | - |
2. 相关成分
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ANXA5 | ANX5; ENX2; HEL-S-7; PP4; RPRGL3 | 4q27 | 25682924 |
| BAX | BCL2L4 | 19q13.33 | 25682924 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 21496227 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 28990249 |
| CCNA1 | CT146 | 13q13.3 | 25682924 |
| CCNB1 | CCNB | 5q13.2 | 25682924 |
| CDK1 | CDC2; CDC28A; P34CDC2 | 10q21.2 | 25682924 |
| CDK4 | CMM3; PSK-J3 | 12q14.1 | 25682924 |
| CDKN1A | CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1 | 6p21.2 | 25682924 |
| DNM1L | DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV; OPA5 | 12p11.21 | 31037132 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Carcinoma, Ovarian Epithelial | disease | 28990249 |
| Diabetes Mellitus, Experimental | disease | 27067643 |
| Diabetes Mellitus, Experimental | disease | 20304443 |
| Glucose tolerance test | phenotype | 20304443 |
| Hyperglycemia | disease | 27067643 |
| Insulin Resistance | phenotype | 22019891 |
| Insulin Resistance | phenotype | 20304443 |
| Left Ventricular Hypertrophy | disease | 31371114 |
| Neoplasms, Glandular and Epithelial | group | 28990249 |
| ovarian neoplasm | disease | 28990249 |
