1. 药材主信息
| 中文名称: | 枳壳 |
| 英文名称: | fruit of Seville orange |
| 拉丁名称: | Fructus Aurantii |
| 使用部位: | unripe fruit |
| 功用: | To regulate the flow of qi, remove its stagnation, and alleviate distension. |
| 适用症: | Phlegm stagnation in chest and diaphragm, glomus in chest, distention in rib-side, food accumulation, retching counterflow. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 13877-91-3 | 罗勒烯 | - | 5281553 |
| 614-35-7 | (-)-辛弗林 | (-)-Synephrine | 854067 |
| 751-29-1 | - | (2E)-3-[(3aS,5aR,6R,7R,9aR,9bR,10aS)-3-(Furan-3-yl)-7-(2-hydroxypropan-2-yl)-3a,6,9a-trimethyl-1,9-dioxododecahydronaphtho[2,1-c]oxireno[d]pyran-6-yl]prop-2-enoic acid | 54611038 |
| 480-41-1 | - | (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one | 667495 |
| 389122-94-5 | (2R)-2-甲基丁酰胺 | (R)-2-Methylbutanamide | 41097729 |
| 489-53-2 | 7-Methoxy-8-(3,3-dimethylglycidyl)-2H-1-benzopyran-2-one | (R)-Meranzin | 3819217 |
| 71353-61-2 | - | 1-Tritriacontanol | 156150 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 501-13-3 | N-(4-氨基丁基)-3-(4-羟基-3-甲氧基苯基)丙烯酰胺 | Feruloylputrescine | 5281796 |
| 520-33-2 | 橙皮素 | Hesperetin | 72281 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 25047426 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27710830 |
| AURKA | AIK; ARK1; AURA; BTAK; PPP1R47; STK15; STK6; STK7 | 20q13.2 | 25047426 |
| BAX | BCL2L4 | 19q13.33 | 25047426 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 25047426 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 27714757 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 25047426 |
| CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | 1p36.21 | 25047426 |
| CTNNB1 | CTNNB; EVR7; MRD19; NEDSDV; armadillo | 3p22.1 | 25047426 |
| CYC1 | MC3DN6; UQCR4 | 8q24.3 | 25047426 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Carcinogenesis | phenotype | 25047426 |
| Chronic liver disease | group | 21354229 |
| Colonic Neoplasms | group | 25047426 |
| Colorectal Neoplasms | group | 27710830 |
| Inflammation | phenotype | 30338847 |
| Liver Failure, Acute | disease | 27714757 |
| Lung Neoplasms | group | 21748601 |
| Necrosis | phenotype | 27710830 |
| Neuroblastoma | disease | 22459762 |
| Non-alcoholic Fatty Liver Disease | disease | 31758699 |
