科华智慧(深圳)创新药物研发有限公司     西北农林科技大学深圳研究院    联合开发

1. 药材主信息

中文名称: 元宝草
英文名称: Sampson StJohn’swort
拉丁名称: Hypericum sampsonii
使用部位: whole herb
功用: To cool blood and stanch bleeding, clear heat and resolve toxin, quicken blood and regulate menstruation, dispel wind and free network vessels.
适用症: Blood ejection, hemoptysis, spontaneous external bleeding, blood strangury, bleeding from wounds, enteritis, dysentery, mammary welling abscess, swollen welling abscess and toxin of clove sore, scalds, snake bite, menstrual disorder, menstrual pain, leukorrhea, knocks and falls, wind-damp impediment pain, pain in lumbus and leg, tinea capitis, mouth sore, eye screen.
毒副作用: -

2. 相关成分

CAS号 中文名称 英文名称 参考文献
11079-53-1 贯叶金丝桃素 Hyperforin 441298
548-04-9 金丝桃素 Hypericin 3663
99481-41-1 5,9-Dihydroxy-3,3-dimethylpyrano[3,2-a]xanthen-12(3H)-one Hyperxanthone 14757909
117-39-5 槲皮素 Quercetin 5280343

3. 相关靶点

基因靶点 基因别名 靶点位置 参考文献
LONP1 CODASS; LON; LONP; LonHS; PIM1; PRSS15; hLON 19p13.3 31683954
MMP9 CLG4B; GELB; MANDP2; MMP-9 20q13.12 20883786
TRPC6 FSGS2; TRP6 11q22.1 23814119
TRPC6 FSGS2; TRP6 11q22.1 27881772
TRPC6 FSGS2; TRP6 11q22.1 31683954
VEGFA MVCD1; VEGF; VPF 6p21.1 20883786
ZFYVE9 MADHIP; NSP; PPP1R173; SARA; SMADIP 1p32.3 31867163

4. 相关疾病

疾病名称 疾病类型 参考文献
Brain Neoplasms group 20883786
Cerebellar Neoplasms group 20883786
Glioblastoma disease 20883786
Medulloblastoma disease 20883786