1. 药材主信息
| 中文名称: | 银不换 |
| 英文名称: | Barbate Cyclea |
| 拉丁名称: | Cyclea barbata |
| 使用部位: | root and stem |
| 功用: | To clear heat and resolve toxin, disperse stasis and relieve pain, disinhibit urine and free strangury. |
| 适用症: | Wind-heat common cold, throat pain, toothache, stomachache, abdominal pain, damp-heat dysentery, malaria, dribbling pain of urination, painful wound from knocks and falls, sprain and contusion. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 2196-60-3 | 衡州乌药碱 | (R)-Coclaurine | 440989 |
| 26137-48-4 | - | 1-Isotetrandrine | 5351212 |
| 17132-74-0 | - | Homoaromoline | 99620 |
| 476-33-5 | - | Homochelidonine | 164609 |
| 477-62-3 | 异粒枝碱 | Isochondrodendrine | 197726 |
| 568-21-8 | - | Isothebaine | 11281 |
| 518-34-3 | 粉防己碱;汉防己甲素 | Tetrandrine | 73078 |
| 22621-72-3 | - | Tetraneurin A | 174868 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AHR | RP85; bHLHe76 | 7p21.1 | 30674869 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 28901537 |
| BECN1 | ATG6; VPS30; beclin1 | 17q21.31 | 24625982 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 24625982 |
| CBL | C-CBL; CBL2; FRA11B; NSLL; RNF55 | 11q23.3 | 30674869 |
| CCND1 | BCL1; D11S287E; PRAD1; U21B31 | 11q13.3 | 29605511 |
| Cd24a | Cd24; HSA; Ly-52; nectadrin | 10 B2|10 23.01 cM | 24212809 |
| CD44 | CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1 | 11p13 | 24212809 |
| CDKN1A | CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1 | 6p21.2 | 29605511 |
| CDKN1B | CDKN4; KIP1; MEN1B; MEN4; P27KIP1 | 12p13.1 | 29605511 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Arthritis | disease | 30674869 |
| Arthritis, Experimental | disease | 29401630 |
| Bone Resorption | phenotype | 30674869 |
| Bone Resorption | phenotype | 29401630 |
| leukemia | disease | 29700286 |
| Liver neoplasms | group | 29334999 |
| Neoplasms | group | 29866132 |
| Neoplasms | group | 24625982 |
| Pancreatic Neoplasm | disease | 29605511 |
