1. 药材主信息
| 中文名称: | 四季青 |
| 英文名称: | Purpleflower Holly Leaf |
| 拉丁名称: | Folium Llicis Chinensis |
| 使用部位: | leaf |
| 功用: | To clearheat and toxic materials. |
| 适用症: | Angina pectoris, coronary heart disease, thrombophlebitis, thromboangiitis obliterans (Buerger’s disease), lung heat cough, swelling pain in throat, dysentery, diarrhea, infection of biliary tract , urinary tract infection, burns and scalds, heat toxin swollen welling abscess, ulcer of lower limb, eczema, frostbite, cracking, wound, bleeding due to external injury. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 175671-49-5 | (2R,4S)-4-羟基哌啶-2-羧酸 | (2R,4S)-4-hydroxypiperidine-2-carboxylic acid | 11389456 |
| 5140-39-6 | - | (5bR,12bS,14S)-5b,6,7,8,12b,14-Hexahydro-10,11,14-trimethoxy-1,3-dioxolo(7,8)(2)benzopyrano(3,4-a)(3)benzazepine | 12309624 |
| 490-79-9 | 2,5-二羟基苯甲酸（龙胆酸） | 2,5-Dihydroxybenzoic acid | 3469 |
| 99-50-3 | 原儿茶酸 | 3,4-Dihydroxybenzoic acid | 72 |
| 2233-18-3 | 3,5-二甲基-4-羟基苯甲醛 | 3,5-Dimethyl-4-hydroxybenzaldehyde | 75222 |
| 645-08-9 | 异香草酸 | 3-Hydroxy-4-methoxybenzoic acid | 12575 |
| 1110-58-3 | - | 7-(8-Formyl-1,7-dihydroxy-5-isopropyl-6-methoxy-3-methyl-2-naphthyl)-2,8-dihydroxy-4-isopropyl-3-methoxy-6-methyl-naphthalene-1-carbaldehyde | 375713 |
| 482-39-3 | 阿福豆苷 | Afzelin | 5316673 |
| 520-36-5 | 芹菜素 | Apigenin | 5280443 |
| 73030-71-4 | 白术内酯III | Atractylenolide III | 155948 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 24107776 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 24107776 |
| ABCG5 | STSL; STSL2 | 2p21 | 24107776 |
| ABCG8 | GBD4; STSL; STSL1 | 2p21 | 24107776 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21871133 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 20840540 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27154977 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31819036 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21168456 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21708244 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 21550230 |
| Blood Pressure | phenotype | 28143892 |
| Brain Neoplasms | group | 26472194 |
| Cognition Disorders | group | 21708244 |
| Colonic Neoplasms | group | 23330808 |
| Colorectal Neoplasms | group | 27472952 |
| Colorectal Neoplasms | group | 22832932 |
| Diabetes | disease | 28707095 |
| Epstein-Barr Virus Infections | group | 28056971 |
| Esophageal Neoplasms | group | 26603620 |
