1. 药材主信息
| 中文名称: | 丝瓜 |
| 英文名称: | Suakwa Vegetablesponge Equivalent plant: Luffa acu |
| 拉丁名称: | Luffa cylindrica |
| 使用部位: | dried vascular bundles of ripe fruit |
| 功用: | To clear heat and resolve phlegm, cool blood and resolve toxin. |
| 适用症: | Febrile diseases with vexation and thirst, cough of phlegm asthma, intestinal wind bleeding, bleeding from hemorrhoids, blood strangury, flooding and spotting, sores with welling abscess and flat abscess, galactostasis, innominate toxin swelling, edema. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 105279-10-5 | 柑属苷B | (2S,3R,4S,5S,6R)-2-[4-[1,3-Dihydroxy-2-[4-[(E)-3-hydroxyprop-1-enyl]-2,6-dimethoxyphenoxy]propyl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | 11972318 |
| 481-18-5 | α-菠菜甾醇 | alpha-Spinasterin | 5281331 |
| 24480-44-2 | - | Bryononic acid | 472768 |
| 372-75-8 | L-瓜氨酸 | Citrulline | 9750 |
| 27740-13-2 | - | Ludovicin A | 168722 |
| 6987-78-6 | - | Olean-12-en-28-oic acid, 3,21-dihydroxy-, gamma-lactone, (3beta,21beta)- | 21594250 |
| 111-02-4 | 角鲨烯 | Squalene | 638072 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ACLY | ACL; ATPCL; CLATP | 17q21.2 | 24690568 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21440986 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 24690568 |
| CASP7 | CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3 | 10q25.3 | 24690568 |
| ERBB2 | CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1 | 17q12 | 24994678 |
| MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | 22q11.22 | 21440986 |
| MTOR | FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS | 1p36.22 | 21440986 |
| PARP1 | ADPRT; ADPRT 1; ADPRT1; ARTD1; PARP; PARP-1; PPOL; pADPRT-1 | 1q42.12 | 24690568 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Bone neoplasms | group | 21440986 |
| Lung Neoplasms | group | 23340170 |
| Neoplasm Metastasis | phenotype | 24994678 |
| Osteosarcoma | disease | 21440986 |
| Prostatic Neoplasms | group | 24690568 |
