科华智慧(深圳)创新药物研发有限公司     西北农林科技大学深圳研究院    联合开发

1. 药材主信息

中文名称: 升麻
英文名称: Largetrifoliolious Bugbane Rhizome
拉丁名称: Rhizoma Cimicifugae
使用部位: rhizome
功用: To induce perspiration and promote eruption, to remove toxic heat, and to cure drooping and ptosis.
适用症: Prevention of ptosis, women’s hormone dysfunction diseases, seasonal epidemic fire toxin, mouth sore, sore pharynx, macula, cold-heat headache, swelling toxin of welling abscess and sore, center qi fall, spleen vacuity diarrhea, chronic dysentery, vaginal discharge, flooding.
毒副作用: -

2. 相关成分

CAS号 中文名称 英文名称 参考文献
112-31-2 癸醛 - 8175
14073-97-3 (-)-薄荷酮 (-)-Menthone 26447
77982-63-9 - (1S,5R)-6,6-dimethylnorpinan-2-one 157139
17430-12-5 - (3R,6E)-nerolidol 11241545
2363-88-4 反式-2,4-癸二烯醛 2,4-Decadienal 5283349
21905-60-2 - 2-(2-Methoxyphenoxy)phenol 572803
1197-01-9 1,1-Dimethyl-2-(4-Methylphenyl)Ethanol 2-(4-Methylphenyl)propan-2-ol 14529
1072-83-9 2-乙酰吡咯 2-Acetylpyrrole 14079
149-30-4 2-巯基苯并噻唑 2-Mercaptobenzothiazole 697993
18829-56-6 反-2-壬烯醛 2-Nonenal 5283335

3. 相关靶点

基因靶点 基因别名 靶点位置 参考文献
ABCB11 ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP 2q31.1 24107776
ABCC2 ABC30; CMOAT; DJS; MRP2; cMRP 10q24.2 24107776
ABCG5 STSL; STSL2 2p21 24107776
ABCG8 GBD4; STSL; STSL1 2p21 24107776
AGT ANHU; SERPINA8; hFLT1 1q42.2 21844078
AHR RP85; bHLHe76 7p21.1 30831189
AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA 14q32.33 24486741
AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA 14q32.33 31406198
AMH MIF; MIS 19p13.3 23478658
APP AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 21q21.3 24107941

4. 相关疾病