1. 药材主信息
| 中文名称: | 木通 |
| 英文名称: | Akebia, Clematis stem |
| 拉丁名称: | Caulis Aristolochiae seu Clematis |
| 使用部位: | stem |
| 功用: | 1. To promote water metabolism and relieve abnormal urination; 2. To clear heat and promote lactation |
| 适用症: | Acute urethritis, short voidings of reddish urine, strangury-turbidity, edema, nephritis with edema, galactostasis, heat vexation in chest, throat pain, mouth sore, tongue sores, wind-damp impediment pain, galactostasis, amenorrhea, dysmenorrhea. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 259140-24-4 | - | 1,4-Dideoxy-1,4-imino-d-arabinitol | 451991 |
| 19130-96-2 | 1-脱氧野尻霉素 | 1-Deoxynojirimycin | 29435 |
| 557-61-9 | 1-二十八烷醇 | 1-Octacosanol | 68406 |
| 2858-66-4 | - | 1-[(2R)-piperidin-2-yl]propan-2-one | 3034881 |
| 67-47-0 | 5-羟甲基糠醛 | 5-Hydroxymethylfurfural | 237332 |
| 73-24-5 | 腺嘌呤 | Adenine | 190 |
| 104777-60-8 | - | Akebonic Acid | 14036559 |
| 313-67-7 | 马兜铃酸A | Aristolochic acid | 2236 |
| 1261395-75-8 | 马兜铃酸D | Aristolochic acid d | 161218 |
| 475-80-9 | 马兜铃酸B | Aristolochic acid II | 108168 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 24107776 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 24107776 |
| ABCG5 | STSL; STSL2 | 2p21 | 24107776 |
| ABCG8 | GBD4; STSL; STSL1 | 2p21 | 24107776 |
| APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | 21q21.3 | 24107941 |
| BACE1 | ASP2; BACE; HSPC104 | 11q23.3 | 24107941 |
| CAT | - | 11p13 | 24559844 |
| CEBPA | C/EBP-alpha; CEBP | 19q13.11 | 29141998 |
| CEBPB | C/EBP-beta; IL6DBP; NF-IL6; TCF5 | 20q13.13 | 26538209 |
| CYP2E1 | CPE1; CYP2E; P450-J; P450C2E | 10q26.3 | 24559844 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Alzheimer's Disease | disease | 30447302 |
| Body Weight | phenotype | 24559844 |
| Head and Neck Neoplasms | group | 30339884 |
| Head and Neck Neoplasms | group | 28012440 |
| Liver diseases | group | 24107776 |
| Obesity | disease | 24559844 |
| Obesity | disease | 29141998 |
| Pain | phenotype | 22646533 |
| Pancreatic Neoplasm | disease | 23108405 |
