1. 药材主信息
| 中文名称: | 马钱子 |
| 英文名称: | Nux Vomica |
| 拉丁名称: | Semen Strychni |
| 使用部位: | seed |
| 功用: | To promote the flow of qi and blood in the collaterals, relieve pain, and promote the subsidence of swelling. |
| 适用症: | Hemiplegia, numbness and paralysis, muscle weakness, impotence, hypertrophic spinitis, chronic anemia, wind-damp intractable impediment, sequel of poliomyelitis, rheumatoid arthritis, knocks and falls, swelling pain of welling abscess and flat abscess. |
| 毒副作用: | Extremely Toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 17241-59-7 | 2-羟甲基蒽醌 | 2-(Hydroxymethyl)anthraquinone | 87014 |
| 1103-85-1 | - | 2-Hydroxy-3-methoxystrychnine | 21680050 |
| 99-96-7 | 对羟基苯甲酸 | 4-Hydroxybenzoic acid | 135 |
| 156-38-7 | 对羟基苯乙酸 | 4-Hydroxyphenylacetic acid | 127 |
| 22595-26-2 | - | 4-Hydroxystrychnine | 211181 |
| 33118-34-2 | - | 5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarbaldehyde | 73687 |
| 41547-82-4 | 腺苷 | Adenosine | 60961 |
| 1476-53-5 | 新生霉素钠 | Albamycin;Cathomycin | 54730021 |
| 509-44-4 | - | Alpha-Colubrine | 12303796 |
| 509-36-4 | - | beta-Colubrine | 251890 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCB11 | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP | 2q31.1 | 24107776 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 24107776 |
| ABCG5 | STSL; STSL2 | 2p21 | 24107776 |
| ABCG8 | GBD4; STSL; STSL1 | 2p21 | 24107776 |
| ADORA2A | A2aR; ADORA2; RDC8 | 22q11.23 | 25772255 |
| AHR | RP85; bHLHe76 | 7p21.1 | 22533375 |
| AKR1B1 | ADR; ALDR1; ALR2; AR | 7q33 | 21712449 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24471788 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 25754463 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31251107 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Alzheimer's Disease | disease | 27933142 |
| Brain Ischemia | disease | 29426336 |
| Cancer cachexia | disease | 27493875 |
| Carcinoma, Ehrlich Tumor | disease | 23348691 |
| Cognition Disorders | group | 21708244 |
| Colonic Neoplasms | group | 23330808 |
| Colorectal Neoplasms | group | 27472952 |
| Colorectal Neoplasms | group | 22832932 |
| Diabetes Mellitus, Experimental | disease | 30624028 |
| Diabetes Mellitus, Experimental | disease | 25754463 |
