1. 药材主信息
| 中文名称: | 两头尖 |
| 英文名称: | Radde Anemone Rhizome |
| 拉丁名称: | Rhizoma Ahemones Daddeae |
| 使用部位: | - |
| 功用: | To relieve rheumatic conditions, and to cure carbuncle. |
| 适用症: | Treatment of rheumatoid arthritis with muscular contracture and joint pain, carbuncle with ulceration. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 7785-70-8 | (1R)-(+)-alpha-蒎烯 | (+)-alpha-Pinene | 82227 |
| 99282-79-8 | 2-(CARBOXYMETHYL-AMINO)-4-CHLORO-BENZOIC ACID | 2-((Carboxymethyl)amino)-4-chlorobenzoic acid | 11107141 |
| 110-43-0 | - | 2-Heptanone | 8051 |
| 589-91-3 | - | 4-Methylcyclohexanol | 11524 |
| 64855-00-1 | Lappaol C | 4-[[3-[1,3-Dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-2-yl]-4-hydroxy-5-methoxyphenyl]methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one | 323896 |
| 90921-11-2 | 白头翁素 | Anemonin | 10496 |
| 7770-78-7 | 牛蒡子苷元 | Arctigenin | 64981 |
| 20362-31-6 | 牛蒡子苷 | Arctiin | 100528 |
| 100-52-7 | 苯甲醛 | Benzaldehyde | 240 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 26335809 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 29515110 |
| MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | 22q11.22 | 22461009 |
| MAPK14 | CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; p38ALPHA | 6p21.31 | 21195543 |
| MAPK3 | ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK | 16p11.2 | 22461009 |
| MTOR | FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS | 1p36.22 | 29515110 |
| PDCD1 | CD279; PD-1; PD1; SLEB2; hPD-1; hPD-l; hSLE1 | 2q37.3 | 30305604 |
| PDE4D | ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4DN2; STRK1 | 5q11.2-q12.1 | 26335809 |
| PDK1 | - | 2q31.1 | 26335809 |
| PRKAA1 | AMPK; AMPKa1 | 5p13.1 | 22095235 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Asthma | disease | 26335809 |
| Bone Resorption | phenotype | 29515110 |
| Glucose Metabolism Disorders | group | 22095235 |
| melanoma | disease | 30305604 |
| Osteolysis | phenotype | 29515110 |
