1. 药材主信息
| 中文名称: | 苦甘草 |
| 英文名称: | root of Foxtail - like sophora |
| 拉丁名称: | Herba Sophorae Alopecuroidis |
| 使用部位: | Sophora alopecuroides L. |
| 功用: | 1. To clear heat and toxic material, deprive dampness and kill parasites. For sorethroat, dysentery, trichomonas enteritis, toothache, stomachache and leucorrhagia, external use for tinea and eczema. 2. To relieve dyspnea and cough. 3. Anticarcinogenic. For malignant hydatidiform mole, chorionic epithelioma and leukemia. |
| 适用症: | 1. To clear heat and toxic material, deprive dampness and kill parasites. For sorethroat, dysentery, trichomonas enteritis, toothache, stomachache and leucorrhagia, external use for tinea and eczema. 2. To relieve dyspnea and cough. 3. Anticarcinogenic. F |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 519-02-8 | 苦参碱 | Matrine | 91466 |
| 145572-44-7 | 槐果碱 | Sophocarpine | 115269 |
| 6882-68-4 | 槐定碱 | Sophoridine | 165549 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 25886453 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 26945965 |
| CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | 2q33.1 | 25886453 |
| CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | 1p36.21 | 25886453 |
| CTNNB1 | CTNNB; EVR7; MRD19; NEDSDV; armadillo | 3p22.1 | 26945965 |
| EPHB2 | BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5; PCBC; Tyro5 | 1p36.12 | 28893319 |
| GSK3B | - | 3q13.33 | 26945965 |
| IGF1 | IGF; IGF-I; IGFI; MGF | 12q23.2 | 25886453 |
| IL6 | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 | 7p15.3 | 25886453 |
| ITK | EMT; LPFS1; LYK; PSCTK2 | 5q33.3 | 26945965 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Head and Neck Neoplasms | group | 28571917 |
| Liver neoplasms | group | 26945965 |
| Multiple Myeloma | disease | 25886453 |
| Pancreatic Neoplasm | disease | 28893319 |
