1. 药材主信息
| 中文名称: | 黄连 |
| 英文名称: | rhizome of Chinese Goldthread |
| 拉丁名称: | Rhizoma Coptidis |
| 使用部位: | rhizome |
| 功用: | To remove damp-heat, quench fire and counteract toxicity. |
| 适用症: | Febrile infectious diseases, dysentery, blood ejection, spontaneous external bleeding, diphtheria, infection of upper respiratory tract, scarlatina, typhoid fever, acute conjunctivitis, otitis media, acute surgical infection, septicemia, hepatitis, trichomoniasis, eruptive dermatitis, hypertension, vexation and agitation, clouded spirit with delirious speech, damp-heat glomus in chest, damp-heat diarrhea dysentery, insomnia and vexation due to effulgent fire, stomach heat vomiting, swift digestion with rapid hungering, red eyes with pain due to liver fire, heat toxin sores, clove sore running yellow, gum swelling and pain, mouth sore, tongue sores, genital swelling, bleeding from hemorrhoids, eczema, scalds. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 751-29-1 | - | (2E)-3-[(3aS,5aR,6R,7R,9aR,9bR,10aS)-3-(Furan-3-yl)-7-(2-hydroxypropan-2-yl)-3a,6,9a-trimethyl-1,9-dioxododecahydronaphtho[2,1-c]oxireno[d]pyran-6-yl]prop-2-enoic acid | 54611038 |
| 2086-96-6 | - | (R)-Canadine | 443422 |
| 3391-86-4 | 1-辛烯-3-醇 | 1-Octen-3-OL | 18827 |
| 30361-28-5 | (2E,4E)-2,4-辛二烯醛 | 2,4-Octadienal | 5283329 |
| 490-79-9 | 2,5-二羟基苯甲酸（龙胆酸） | 2,5-Dihydroxybenzoic acid | 3469 |
| 2548-87-0 | E-2-辛烯醛 | 2-Octenal | 5283324 |
| 69809-24-1 | - | 5,8-Dihydroxy-2-(2-phenylethyl)chromone | 129670 |
| 69809-24-1 | - | 5,8-Dihydroxy-2-(2-phenylethyl)chromone | 129670 |
| 1820-89-9 | - | 5-(beta-D-glucopyranosyloxy)-2-hydroxybenzoic acid | 10914066 |
| 493-49-2 | 6,7-二甲氧基-3,4-二氢-异喹啉-1-酮 | 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one | 610097 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ADRB2 | ADRB2R; ADRBR; B2AR; BAR; BETA2AR | 5q32 | 26746354 |
| AHR | RP85; bHLHe76 | 7p21.1 | 30674869 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 26746354 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24486741 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 28901537 |
| ANXA5 | ANX5; ENX2; HEL-S-7; PP4; RPRGL3 | 4q27 | 25682924 |
| BAX | BCL2L4 | 19q13.33 | 25682924 |
| BECN1 | ATG6; VPS30; beclin1 | 17q21.31 | 24625982 |
| CASP1 | ICE; IL1BC; P45 | 11q22.3 | 31336157 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 21496227 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Arthritis | disease | 30674869 |
| Arthritis, Experimental | disease | 29401630 |
| Bone Resorption | phenotype | 30674869 |
| Bone Resorption | phenotype | 29401630 |
| Brain Ischemia | disease | 30414381 |
| Carcinoma, Ovarian Epithelial | disease | 28990249 |
| Cystadenocarcinoma, Serous | disease | 29879497 |
| Diabetes Mellitus, Experimental | disease | 27067643 |
| Diabetes Mellitus, Experimental | disease | 20304443 |
| Glucose tolerance test | phenotype | 20304443 |
