1. 药材主信息
| 中文名称: | 汉防己 |
| 英文名称: | Yellowmouth Dutchmanspipe |
| 拉丁名称: | Aristolochia heterophylla |
| 使用部位: | root |
| 功用: | To dispel wind and relieve pain, clear heat and disinhibit water. |
| 适用症: | Rheumatic pain in joints, damp-heat pain in limbs, edema, inhibited urination, beriberi with edema. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 79185-75-4 | - | 9-Hydroxy-8-methoxy-6-nitro-phenanthrol[3,4-D][1,3]dioxole-5-carboxylic acid | 1941 |
| 313-67-7 | 马兜铃酸A | Aristolochic acid | 2236 |
| 18556-27-9 | 汉防己丙素 | Cyclanoline | 3082134 |
| 436-77-1 | 防己诺林碱;汉防已乙素 | Fangchinoline | 73481 |
| 2141-09-5 | 木兰花碱 | Magnoflorine | 73337 |
| 518-34-3 | 粉防己碱;汉防己甲素 | Tetrandrine | 73078 |
| 22621-72-3 | - | Tetraneurin A | 174868 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AHR | RP85; bHLHe76 | 7p21.1 | 30674869 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 28901537 |
| ATG5 | APG5; APG5-LIKE; APG5L; ASP; SCAR25; hAPG5 | 6q21 | 21418191 |
| BECN1 | ATG6; VPS30; beclin1 | 17q21.31 | 24625982 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 24625982 |
| CBL | C-CBL; CBL2; FRA11B; NSLL; RNF55 | 11q23.3 | 30674869 |
| CCND1 | BCL1; D11S287E; PRAD1; U21B31 | 11q13.3 | 29605511 |
| Cd24a | Cd24; HSA; Ly-52; nectadrin | 10 B2|10 23.01 cM | 24212809 |
| CD44 | CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1 | 11p13 | 24212809 |
| CDKN1A | CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1 | 6p21.2 | 29605511 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Arthritis | disease | 30674869 |
| Arthritis, Experimental | disease | 29401630 |
| Bone Resorption | phenotype | 30674869 |
| Bone Resorption | phenotype | 29401630 |
| leukemia | disease | 29700286 |
| Liver neoplasms | group | 21418191 |
| Liver neoplasms | group | 29334999 |
| Neoplasms | group | 29866132 |
| Neoplasms | group | 24625982 |
| Pancreatic Neoplasm | disease | 29605511 |
