1. 药材主信息
| 中文名称: | 贯叶连翘 |
| 英文名称: | Common StJohn’swort |
| 拉丁名称: | Hypericum perforatum |
| 使用部位: | whole herb with root |
| 功用: | To promote astriction and stanch bleeding, regulate menstruation and free milk, clear heat and resolve toxin, disinhibit damp. |
| 适用症: | Hemoptysis, blood ejection, intestinal wind bleeding, flooding and spotting, bleeding due to external injury, menstrual disorder, galactostasis, jaundice, throat pain, red eyes with gall, urinary tract infection, mouth sore, nose sores, swelling toxin of welling abscess and boil, burns and scalds. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 101140-06-1 | 3,8''-Biapigenin | 3,8'-Biapigenin | 10414856 |
| 490-46-0 | 表儿茶素 | EC;Epicatechin | 72276 |
| 11079-53-1 | 贯叶金丝桃素 | Hyperforin | 441298 |
| 548-04-9 | 金丝桃素 | Hypericin | 3663 |
| 1401-55-4 | - | Liquidambar styraciflua | 16133892 |
| 55954-61-5 | 伪金丝桃素 | Pseudohypericin | 4978 |
| 117-39-5 | 槲皮素 | Quercetin | 5280343 |
| 522-12-3 | 槲皮苷 | Quercitrin | 5280459 |
| 153-18-4 | 芦丁 | Rutin | 5280805 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27017346 |
| CDH1 | Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO | 16q22.1 | 27017346 |
| CXCL1 | FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1 | 4q13.3 | 25281414 |
| IFNG | IFG; IFI | 12q15 | 25281414 |
| IL1B | IL-1; IL1-BETA; IL1F2; IL1beta | 2q14.1 | 25281414 |
| LONP1 | CODASS; LON; LONP; LonHS; PIM1; PRSS15; hLON | 19p13.3 | 31683954 |
| MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | 22q11.22 | 27017346 |
| MMP9 | CLG4B; GELB; MANDP2; MMP-9 | 20q13.12 | 20883786 |
| MPO | - | 17q22 | 25281414 |
| PPARGC1A | LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1 | 4p15.2 | 28049156 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Atherosclerosis | disease | 27017346 |
| Brain Neoplasms | group | 20883786 |
| Cerebellar Neoplasms | group | 20883786 |
| Colitis | disease | 25281414 |
| Diabetes | disease | 28049156 |
| Diabetes Mellitus, Experimental | disease | 26185015 |
| Diabetic Cardiomyopathies | disease | 26185015 |
| Diabetic Nephropathy | disease | 21195168 |
| Glioblastoma | disease | 20883786 |
| Ischemia | phenotype | 27017346 |
