1. 药材主信息
| 中文名称: | 粉防己 |
| 英文名称: | Stephania tetrandra |
| 拉丁名称: | Radix Stephaniae Tetrandrae |
| 使用部位: | Stephania tetrandra S. Moore |
| 功用: | For arthralgia, especially of heat type, also for acrodynia of dampness-heat type, trauma, periarthritis of joint and angina pectoris. For edema nad dysuria. In ancient times, used for dyspneic cough due to withered lung or heat-heat, for hemoptysis with abundant expectoration due to withered lung, used together with Semen Lepidii seu Descurainiae. Recently, use for bronchial asthma, asthmatic bronchitis, silicosis, pulmonary tuberculosis, etc. For hypertension, especially that complicated by coronary heart diseases. For carcinoma of lung, and squamous cell epithioma(decreasing the dosage of radiotherapy by one-third to one-fourth and minimizing the occurrence of side effect). |
| 适用症: | 1. Hanfangchin A and B are two active components, which have an anti-inflammatory effect.2. Anti-allergic, inhibiting the release of histamine.3. Promting phagocytosis.4. Dilating coronary artery and decreasing myocardial oxygen consumption.5. Inhibiting the growth of Bacillus tuberculosis, Staphylococcus aureus and ameba.6. High dosage may induce respiratory inhibition and cardiac arrest. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 18556-27-9 | 汉防己丙素 | Cyclanoline | 3082134 |
| 436-77-1 | 防己诺林碱;汉防已乙素 | Fangchinoline | 73481 |
| 518-34-3 | 粉防己碱;汉防己甲素 | Tetrandrine | 73078 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AHR | RP85; bHLHe76 | 7p21.1 | 30674869 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 28901537 |
| ATG5 | APG5; APG5-LIKE; APG5L; ASP; SCAR25; hAPG5 | 6q21 | 21418191 |
| BECN1 | ATG6; VPS30; beclin1 | 17q21.31 | 24625982 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 24625982 |
| CBL | C-CBL; CBL2; FRA11B; NSLL; RNF55 | 11q23.3 | 30674869 |
| CCND1 | BCL1; D11S287E; PRAD1; U21B31 | 11q13.3 | 29605511 |
| Cd24a | Cd24; HSA; Ly-52; nectadrin | 10 B2|10 23.01 cM | 24212809 |
| CD44 | CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1 | 11p13 | 24212809 |
| CDKN1A | CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1 | 6p21.2 | 29605511 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Arthritis | disease | 30674869 |
| Arthritis, Experimental | disease | 29401630 |
| Bone Resorption | phenotype | 30674869 |
| Bone Resorption | phenotype | 29401630 |
| leukemia | disease | 29700286 |
| Liver neoplasms | group | 21418191 |
| Liver neoplasms | group | 29334999 |
| Neoplasms | group | 29866132 |
| Neoplasms | group | 24625982 |
| Pancreatic Neoplasm | disease | 29605511 |
