科华智慧(深圳)创新药物研发有限公司     西北农林科技大学深圳研究院    联合开发

1. 药材主信息

中文名称: 丁公藤
英文名称: Stem of Taiwan Erycibe
拉丁名称: Caulis Erycibes
使用部位: rattan
功用: To dispel wind and deprive dampness, reduce swelling, relieve pain.
适用症: Wind-damp impediment pain, hemiplegia, painful swelling from knocks and falls.
毒副作用: Toxic

2. 相关成分

CAS号 中文名称 英文名称 参考文献
465-18-9 猪苓酸C (2R)-2-[(5R,10S,13R,14R,16R,17R)-16-hydroxy-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid 9805290
6451-73-6 金黄紫堇碱 (S)-Scoulerine 439654
32466-54-9 反式-2-十二烷烯酸 2-Dodecenoic acid 5282729
167775-55-5 - 25-Hydroxy-3-Epidehydrotumulosic Acid 10368709
57378-72-0 4,5-二-O-咖啡酰奎宁酸(异绿原酸C) 3,4-Dicaffeoylquinic acid 6474309
167775-54-4 3-表去氢土莫酸 3-Epidehydrotumulosic acid 10005581
623-05-2 对羟基苯甲醇 4-Hydroxybenzyl alcohol 125
73-24-5 腺嘌呤 Adenine 190
4176-06-1 芳-姜黄烯 Ar-Curcumene 3083834
74239-84-2 - Bao gong teng A 156282

3. 相关靶点

基因靶点 基因别名 靶点位置 参考文献
CAT - 11p13 24559844
CHRNA7 CHRNA7-2; NACHRA7 15q13.3 31560162
CYP2E1 CPE1; CYP2E; P450-J; P450C2E 10q26.3 24559844
EIF2S1 EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A 14q23.3 24215632
GAS6 AXLLG; AXSF 13q34 30716432
GCG GLP-1; GLP1; GLP2; GRPP 2q24.2 23471488
NFE2L2 HEBP1; IMDDHH; NRF2; Nrf-2 2q31.2 30716432
NFKB1 CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB 4q24 23612072
PPARG CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma 3p25.2 23612072
PRKAA1 AMPK; AMPKa1 5p13.1 24559844

4. 相关疾病

疾病名称 疾病类型 参考文献
Acute kidney injury disease 30716432
Aging phenotype 24932939
Alzheimer's Disease disease 31560162
Body Weight phenotype 24559844
Colonic Neoplasms group 23612072
Down Syndrome disease 24932939
Hyperglycemia disease 23471488
leukemia disease 24215632
Obesity disease 24559844
Reperfusion Injury disease 30716432