1. 药材主信息
| 中文名称: | 大籽雪胆 |
| 英文名称: | Largeseed Hemsleya |
| 拉丁名称: | Hemsleya macrosperma |
| 使用部位: | tuberoid |
| 功用: | See Hemsleya amabilis. |
| 适用症: | See Hemsleya amabilis. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 28973-67-3 | - | 23,24-dihydrocucurbitacin E | 21577087 |
| 2222-07-3 | 葫芦素 I | Cucurbitacin I | 5281321 |
| 50298-90-3 | 雪胆素乙 | Cucurbitacin IIb | 10481797 |
| 55903-92-9 | - | Cucurbitacin R | 180535 |
| 13201-14-4 | 二氢葫芦素B | Dihydrocucurbitacin B | 267250 |
| 27304-02-5 | - | Dihydrocyperaquinone | 33771 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ACLY | ACL; ATPCL; CLATP | 17q21.2 | 24690568 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21440986 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 21225866 |
| BCL2L1 | BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 | 20q11.21 | 21225866 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 24690568 |
| CASP7 | CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3 | 10q25.3 | 24690568 |
| ERBB2 | CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1 | 17q12 | 24994678 |
| GADD45A | DDIT1; GADD45 | 1p31.3 | 26890145 |
| MAP1LC3A | ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3 | 20q11.22 | 22441021 |
| MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | 22q11.22 | 21440986 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Bone neoplasms | group | 21440986 |
| Lung Neoplasms | group | 23340170 |
| Lung Neoplasms | group | 21225866 |
| Neoplasm Metastasis | phenotype | 24994678 |
| Neoplasm Metastasis | phenotype | 21225866 |
| Osteosarcoma | disease | 21440986 |
| Prostatic Neoplasms | group | 24690568 |
| Stomach Neoplasms | group | 26890145 |
