1. 药材主信息
| 中文名称: | 大叶钩藤 |
| 英文名称: | Largeleaf Gambirplant |
| 拉丁名称: | Uncaria macrophylla |
| 使用部位: | hooked stem-branch |
| 功用: | See Uncaria rhynchophylla. |
| 适用症: | See Uncaria rhynchophylla. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 14901-07-6 | β-紫罗兰酮 | - | 638014 |
| 13063-54-2 | D-四氢药根碱 | (+)-Corypalmine | 12304090 |
| 56797-40-1 | (Z)-7-Hexadecenal | (Z)-7-Hexadecenal | 5364438 |
| 30364-38-6 | 1,2-Dihydro-1,1,6-trimethylnaphthalene | 1,1,6-Trimethyl-1,2-dihydronaphthalene | 121677 |
| 488-23-3 | 1，2，3，4-四甲基苯 | 1,2,3,4-Tetramethylbenzene | 10263 |
| 66851-47-6 | - | 1,2-Benzenedi(carboxylic-14C)acid, dibutyl ester | 171810 |
| 90-12-0 | - | 1-Methylnaphthalene | 7002 |
| 2363-88-4 | 反式-2,4-癸二烯醛 | 2,4-Decadienal | 5283349 |
| 472-66-2 | - | 2,6,6-Trimethyl-1-cyclohexene-1-acetaldehyde | 61124 |
| 4179-19-5 | 3,5-二甲氧基甲苯 | 3,5-Dimethoxytoluene | 77844 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21168456 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21708244 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24000005 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27472952 |
| APP | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 | 21q21.3 | 28933595 |
| BBC3 | JFY-1; JFY1; PUMA | 19q13.32 | 24389342 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 22832932 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 27472952 |
| BCL2L1 | BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 | 20q11.21 | 22832932 |
| BCL2L1 | BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 | 20q11.21 | 27472952 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Cognition Disorders | group | 21708244 |
| Colonic Neoplasms | group | 23330808 |
| Colorectal Neoplasms | group | 27472952 |
| Colorectal Neoplasms | group | 22832932 |
| Diabetic Nephropathy | disease | 21195168 |
| Inflammation | phenotype | 21708244 |
| leukemia | disease | 23584398 |
| leukemia | disease | 21950524 |
| Liver Cirrhosis, Experimental | disease | 21168456 |
| Liver neoplasms | group | 27036874 |
